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Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts

dc.contributor.authorSilventoinen, Karri
dc.contributor.authorPiirtola, Maarit
dc.contributor.authorJelenkovic Moreno, Aline
dc.contributor.authorSund, Reijo
dc.contributor.authorTarnoki, Adam D.
dc.contributor.authorTarnoki, David L.
dc.contributor.authorMedda, Emanuela
dc.contributor.authorNisticò, Lorenza
dc.contributor.authorToccaceli, Virgilia
dc.contributor.authorHonda, Chika
dc.contributor.authorInui, Fujio
dc.contributor.authorTomizawa, Rie
dc.contributor.authorWatanabe, Mikio
dc.contributor.authorSakai, Norio
dc.contributor.authorGatz, Margaret
dc.contributor.authorButler, David A.
dc.contributor.authorLee, Jooyeon
dc.contributor.authorLee, Sooji
dc.contributor.authorSung, Joohon
dc.contributor.authorFranz, Carol E.
dc.contributor.authorKremen, William S.
dc.contributor.authorLyons, Michael J.
dc.contributor.authorDerom, Catherine A.
dc.contributor.authorVlietinck, Robert F.
dc.contributor.authorLoos, Ruth J. F.
dc.contributor.authorTynelius, Per
dc.contributor.authorRasmussen, Finn
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMedland, Sarah E.
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorBrandt, Ingunn
dc.contributor.authorNilsen, Thomas S.
dc.contributor.authorHarris, Jennifer R.
dc.contributor.authorTyler, Jessica
dc.contributor.authorHopper, John L.
dc.contributor.authorMagnusson, Patrik K. E.
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorDahl Aslan, Anna K.
dc.contributor.authorOrdoñana Martín, Juan Ramón
dc.contributor.authorSánchez Romera, Juan Francisco
dc.contributor.authorColodro Conde, Lucía
dc.contributor.authorRebato Ochoa, Esther Matilde
dc.contributor.authorZhang, Dongfeng
dc.contributor.authorPang, Zengchang
dc.contributor.authorTan, Qihua
dc.contributor.authorSilberg, Judy L.
dc.contributor.authorMaes, Hermine H.
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorSørensen, Thorkild I. A.
dc.contributor.authorKorhonen, Tellervo
dc.contributor.authorKaprio, Jaakko
dc.date.accessioned2022-10-24T15:39:48Z
dc.date.available2022-10-24T15:39:48Z
dc.date.issued2022
dc.identifier.citationScientific Reports 12 : (2022) // Article ID 13148es_ES
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10810/58178
dc.description.abstractWe tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally control for background genetic and childhood social factors. Data from 18 cohorts including 10,527 monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs discordant for education and smoking were analyzed by linear fixed effects regression models. Within twin pairs, education levels were lower among the currently smoking than among the never smoking co-twins and this education difference was larger within DZ than MZ pairs. Similarly, education levels were higher among former smoking than among currently smoking co-twins, and this difference was larger within DZ pairs. Our results support the hypothesis of a causal effect of education on both current smoking status and smoking cessation. However, the even greater intra-pair differences within DZ pairs, who share only 50% of their segregating genes, provide evidence that shared genetic factors also contribute to these associations.es_ES
dc.description.sponsorshipThis study was conducted within the CODATwins project. Open access funded by Helsinki University Library. Support for collaborators: This research was facilitated through access to Twins Research Australia, a national resource supported by a Centre of Research Excellence Grant (ID: 1079102), from the National Health and Medical Research Council. Data collection and analyses in Finnish twin cohorts have been supported by ENGAGE - European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007, Grant Agreement Number 201413, National Institute of Alcohol Abuse and Alcoholism (Grants AA-12502, AA-00145, and AA-09203 to R J Rose, the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant Numbers: 213506, 129680), and the Academy of Finland (Grants 100499, 205585, 118555, 141054, 265240, 263278 and 264146 to J Kaprio). Since its origin the East Flanders Prospective Survey has been partly supported by Grants from the Fund of Scientific Research, Flanders and Twins, a non-profit Association for Scientific Research in Multiple Births (Belgium). Anthropometric measurements of the Hungarian twins were supported by Medexpert Ltd., Budapest, Hungary. Korean Twin-Family Register was supported by the Global Research Network Program of the National Research Foundation (NRF 2011-220-E00006). The Murcia Twin Registry is supported by Fundacion Seneca, Regional Agency for Science and Technology, Murcia, Spain (19479/PI/14) and Ministry of Science and Innovation, Spain (RTI2018-095185-B-I00, co-funded by European Regional Development Fund (FEDER)). Osaka University Aged Twin Registry is supported by Grants from JSPS KAKENHI JP (23593419, 24792601, 26671010, 24590695, 26293128, 16K15385, 16K15978, 16K15989, 16H03261). The Swedish Twin Registry is managed by Karolinska Institutet and receives funding through the Swedish Research Council under the Grant No. 2017-00641. Vietnam Era Twin Study of Aging was supported by National Institute of Health Grants NIA R01 AG018384, R01 AG018386, R01 AG022381, and R01 AG022982. The Cooperative Studies Program of the Office of Research & Development of the United States Department of Veterans Affairs has provided financial support for the development and maintenance of the Vietnam Era Twin (VET) Registry. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the NIA/NIH, or the VA. The NAS-NRC Twin Registry acknowledges financial support from the National Institutes of Health Grant Number R21 AG039572.es_ES
dc.language.isoenges_ES
dc.publisherNaturees_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/201413es_ES
dc.relationinfo:eu-repo/grantAgreement/MICIU/RTI2018-095185-B-I00es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectmaternal smokinges_ES
dc.subjectadolescencees_ES
dc.subjectpregnancyes_ES
dc.titleSmoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohortses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons. org/ licenses/ by/4. 0/es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-022-17536-xes_ES
dc.identifier.doi10.1038/s41598-022-17536-x
dc.contributor.funderEuropean Commission
dc.departamentoesGenética, antropología física y fisiología animales_ES
dc.departamentoeuGenetika,antropologia fisikoa eta animalien fisiologiaes_ES


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© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons. org/ licenses/ by/4. 0/
Except where otherwise noted, this item's license is described as © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons. org/ licenses/ by/4. 0/