dc.contributor.author | Morales Matías, Amaia | |
dc.contributor.author | Labidi Bouchrika, Jalel | |
dc.contributor.author | Gullón Estévez, Patricia | |
dc.date.accessioned | 2022-11-10T17:11:42Z | |
dc.date.available | 2022-11-10T17:11:42Z | |
dc.date.issued | 2022-09 | |
dc.identifier.citation | Sustainable Materials and Technologies 33 : (2022) // Article ID e00474 | es_ES |
dc.identifier.issn | 2214-9937 | |
dc.identifier.uri | http://hdl.handle.net/10810/58311 | |
dc.description.abstract | So far, the possibility of synthesizing hydrogels based on multiple biopolymers has been investigated, and among them lignin has proven to be one of the potentials for this purpose due to the multiple advantages it offers. However, because of its high molecular weight, steric hindrance and few reactive sites on its structure, it is sometimes necessary to improve its reactivity though chemical modifications. On the basis of previous results, two chemical modifications were selected in order to enhance almond, walnut and commercial alkaline and organosolv lignins' reactivity: a peroxidation reaction for alkaline ones and a hydroxymethylation for organosolv ones. Both reactions were confirmed by multiple techniques (i.e. FTIR, GPC and TGA). Hydrogels were syn-thesized from these lignins according to previous works. The high lignin waste of the synthesized hydrogels suggested that despite the modification of the lignins, just the highest molecular weight fractions reacted with the matrix polymer. Moreover, the swelling capacity of modified alkaline lignin-based hydrogels was negatively affected, whereas the one for organosolv lignin-based samples improved. The SEM micrographs explained the aforementioned, and the results from the DSC and compression tests were in accordance with them. Self -extracted quercetin loading and release studies suggested that these samples could be used for controlled drug delivery. | es_ES |
dc.description.sponsorship | The authors would like to acknowledge the financial support of the Department of Education of the Basque Government (IT1498-22) . A. Morales would like to thank the University of the Basque Country (Training of Researcher Staff, PIF17/207) . P. Gullón would like to acknowledge the Grants for the recruitment of technical support staff (PTA2019-017850-I) under the Spanish State Plan for Scientific and Technical Research and Innovation 2017-2020. The authors thank SGIker (UPV/EHU/ERDF, EU) for their technical and human support. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PTA2019-017850-I | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | modified lignin | es_ES |
dc.subject | peroxidation | es_ES |
dc.subject | hydroxymethylation | es_ES |
dc.subject | hydrogels | es_ES |
dc.subject | drug delivery | es_ES |
dc.title | Influence of lignin modifications on physically crosslinked lignin hydrogels for drug delivery applications | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2214993722000884?via%3Dihub | es_ES |
dc.identifier.doi | 10.1016/j.susmat.2022.e00474 | |
dc.departamentoes | Ingeniería química y del medio ambiente | es_ES |
dc.departamentoeu | Ingeniaritza kimikoa eta ingurumenaren ingeniaritza | es_ES |