Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study)
dc.contributor.author | Valdés, Sergio | |
dc.contributor.author | Doulatram Gamgaram, Viyey | |
dc.contributor.author | Maldonado Araque, Cristina | |
dc.contributor.author | Lago Sampedro, Ana | |
dc.contributor.author | García Escobar, Eva | |
dc.contributor.author | García Serrano, Sara | |
dc.contributor.author | García Vivanco, Marta | |
dc.contributor.author | Garrido, Juan Luis | |
dc.contributor.author | Theobald, Mark Richard | |
dc.contributor.author | Gil, Victoria | |
dc.contributor.author | Martín Llorente, Fernando | |
dc.contributor.author | Ocón, Pilar | |
dc.contributor.author | Calle Pascual, Alfonso | |
dc.contributor.author | Castaño González, Luis Antonio | |
dc.contributor.author | Delgado, Elías | |
dc.contributor.author | Menéndez Torre, Edelmiro | |
dc.contributor.author | Franch Nadal, Josep | |
dc.contributor.author | Gaztambide Sáenz, María Sonia | |
dc.contributor.author | Girbes, Joan | |
dc.contributor.author | Chaves, Felipe J. | |
dc.contributor.author | Galán García, José Luis | |
dc.contributor.author | Aguilera Venegas, Gabriel | |
dc.contributor.author | Gutiérrez Repiso, Carolina | |
dc.contributor.author | Fernández García, José Carlos | |
dc.contributor.author | Colomo, Natalia | |
dc.contributor.author | Soriguer, Federico | |
dc.contributor.author | García Fuentes, Eduardo | |
dc.contributor.author | Rojo Martínez, Gemma | |
dc.date.accessioned | 2022-11-15T15:30:17Z | |
dc.date.available | 2022-11-15T15:30:17Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Environmental Health 21 : (2022) // Article ID 76 | es_ES |
dc.identifier.issn | 1476-069X | |
dc.identifier.uri | http://hdl.handle.net/10810/58351 | |
dc.description.abstract | Background Recent reports have suggested that air pollution may impact thyroid function, although the evidence is still scarce and inconclusive. In this study we evaluated the association of exposure to air pollutants to thyroid function parameters in a nationwide sample representative of the adult population of Spain. Methods The Di@bet.es study is a national, cross-sectional, population-based survey which was conducted in 2008-2010 using a random cluster sampling of the Spanish population. The present analyses included 3859 individuals, without a previous thyroid disease diagnosis, and with negative thyroid peroxidase antibodies (TPO Abs) and thyroid-stimulating hormone (TSH) levels of 0.1-20 mIU/L. Participants were assigned air pollution concentrations for particulate matter <2.5 mu m (PM2.5) and Nitrogen Dioxide (NO2), corresponding to the health examination year, obtained by means of modeling combined with measurements taken at air quality stations (CHIMERE chemistry-transport model). TSH, free thyroxine (FT4), free triiodothyronine (FT3) and TPO Abs concentrations were analyzed using an electrochemiluminescence immunoassay (Modular Analytics E170 Roche). Results In multivariate linear regression models, there was a highly significant negative correlation between PM2.5 concentrations and both FT4 (p<0.001), and FT3 levels (p<0.001). In multivariate logistic regression, there was a significant association between PM2.5 concentrations and the odds of presenting high TSH [OR 1.24 (1.01-1.52) p=0.043], lower FT4 [OR 1.25 (1.02-1.54) p=0.032] and low FT3 levels [1.48 (1.19-1.84) p=<0.001] per each IQR increase in PM2.5 (4.86 mu g/m(3)). There was no association between NO2 concentrations and thyroid hormone levels. No significant heterogeneity was seen in the results between groups of men, pre-menopausal and post-menopausal women. Conclusions Exposures to PM2.5 in the general population were associated with mild alterations in thyroid function. | es_ES |
dc.description.sponsorship | CIBERDEM (Ministerio de Economia, Industria y Competitividad-ISCIII), Ministerio de Sanidad, Servicios Sociales e Igualdad-ISCIII, Instituto de Salud Carlos III (PI17/02136, PI20/01322), Consejeria de Salud y familias (PI-0144-2018), European Regional Development Fund (ERDF) "A way to build Europe". GRM belongs to the regional Nicolas Monardes research program of the Consejeria de Salud (RC-0006-2016; Junta de Andalucia, Spain). CMA is recipient of a "Rio Hortega" research contract (CM19/00186, Instituto de Salud Carlos III). VKDG is recipient of a "Rio Hortega" research contract (CM21/00214, Instituto de Salud Carlos III). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BMC | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | air pollution | es_ES |
dc.subject | thyroid | es_ES |
dc.subject | Spain | es_ES |
dc.title | Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study) | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://ehjournal.biomedcentral.com/articles/10.1186/s12940-022-00889-1 | es_ES |
dc.identifier.doi | 10.1186/s12940-022-00889-1 | |
dc.departamentoes | Pediatría | es_ES |
dc.departamentoeu | Pediatria | es_ES |
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mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.