The Myth of The Annular Lipids
dc.contributor.author | Gómez Fernández, Juan C. | |
dc.contributor.author | Goñi Urcelay, Félix María | |
dc.date.accessioned | 2022-11-18T17:24:43Z | |
dc.date.available | 2022-11-18T17:24:43Z | |
dc.date.issued | 2022-10-22 | |
dc.identifier.citation | Biomedicines 10(11) : (2022) // Article ID 2672 | es_ES |
dc.identifier.issn | 2227-9059 | |
dc.identifier.uri | http://hdl.handle.net/10810/58436 | |
dc.description.abstract | In the early 1970s, the existence of a “lipid annulus” stably surrounding the individual intrinsic protein molecules was proposed by several authors. They referred to a number of lipid molecules in slow exchange with the bulk lipid in the bilayer, i.e., more or less protein-bound, and more ordered than the bulk lipid. The annular lipids would control enzyme activity. This idea was uncritically accepted by most scientists working with intrinsic membrane proteins at the time, so that the idea operated like a myth in the field. However, in the following decade, hard spectroscopic and biochemical evidence showed that the proposed annular lipids were not immobilized for a sufficiently long time to influence enzyme or transporter activity, nor were they ordered by the protein. Surprisingly, forty years later, the myth survives, and the term ‘annular lipid’ is still in use, in a different, but even more illogical sense. | es_ES |
dc.description.sponsorship | This research was funded in part by the Spanish Ministerio de Ciencia e Innovación (MCI), Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) (grant No. PID2021-124461NB-I00), by the Basque Government (grant No. IT1625-22), by Fundación Ramón Areces (CIVP20A6619), by Fundación Biofísica Bizkaia, and by the Basque Excellence Research Centre (BERC) program of the Basque Government. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2021-124461NB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | lipid annulus | es_ES |
dc.subject | annular lipid | es_ES |
dc.subject | boundary lipid | es_ES |
dc.subject | intrinsic membrane proteins | es_ES |
dc.subject | lipid-protein interactions | es_ES |
dc.subject | resonance spectroscopies | es_ES |
dc.title | The Myth of The Annular Lipids | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2022-11-10T14:27:37Z | |
dc.rights.holder | © 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2227-9059/10/11/2672 | es_ES |
dc.identifier.doi | 10.3390/biomedicines10112672 | |
dc.departamentoes | Bioquímica y biología molecular | |
dc.departamentoeu | Biokimika eta biologia molekularra |
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Except where otherwise noted, this item's license is described as © 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).