dc.contributor.author | Álvarez Mora, Iker | |
dc.contributor.author | Bolliet, Valérie | |
dc.contributor.author | López Herguedas, Naroa | |
dc.contributor.author | Castro, Lyen | |
dc.contributor.author | Anakabe Iturriaga, Eneritz | |
dc.contributor.author | Monperrus, Mathilde Elisabeth | |
dc.contributor.author | Etxebarria Loizate, Nestor | |
dc.date.accessioned | 2022-11-24T16:42:10Z | |
dc.date.available | 2022-11-24T16:42:10Z | |
dc.date.issued | 2022-10 | |
dc.identifier.citation | Environmental Pollution 311 : (2022) // Article ID 120016 | es_ES |
dc.identifier.issn | 0269-7491 | |
dc.identifier.issn | 1873-6424 | |
dc.identifier.uri | http://hdl.handle.net/10810/58538 | |
dc.description.abstract | The presence of contaminants of emerging concern in the aquatic environment directly impacts water-living organisms and can alter their living functions. These compounds are often metabolized and excreted, but they can also be accumulated and spread through the food chain. The metabolized contaminants can also lead to the formation of new compounds with unknown toxicity and bioaccumulation potential. In this work, we have studied the occurrence, bioconcentration, and biotransformation of CECs in glass eels (Anguilla anguilla) using UHPLC-HRMS. To select the target CECs, we first carried out an environmental risk assessment of the WWTP effluent that releases directly into the Adour estuary (Bayonne, Basque Country, France). The risk quotients of every detected contaminant were calculated and three ecotoxicologically relevant contaminants were chosen to perform the exposure experiment: propranolol, diazepam, and irbesartan. An experiment of 14 days consisting of 7 days of exposure and 7 days of depuration was carried out to measure the bioconcentration of the chosen compounds. The quantitative results of the concentrations in glass eel showed that diazepam and irbesartan reached BCF approximate to 10 on day 7, but both compounds were eliminated after 7 days of depuration. On the other hand, propranolol's concentration remains constant all along with the experiment, and its presence can be detected even in the non-exposed control group, which might suggest environmental contamination. Two additional suspect screening strategies were used to identify metabolization products of the target compounds and other xenobiotics already present in wild glass eels. Only one metabolite was identified, nordiazepam, a well-known diazepam metabolite, probably due to the low metabolic rate of glass eels at this stage. The xenobiotic screening confirmed the presence of more xenobiotics in wild glass eels, prominent among them, the pharma-ceuticals exemestane, primidone, iloprost, and norethandrolone. | es_ES |
dc.description.sponsorship | Authors gratefully acknowledge financial support from the Agencia Estatal de Investigación (AEI) of Spain and the European Regional Development Fund through project CTM2017–84763-C3–1-R and the Basque Government through the financial support as a consolidated group of the Basque Research System (IT1213–19). Iker Alvarez is grateful to the University of the Basque Country and the Université de Pau et des Pays de L′ Adour for his cotutelle predoctoral scholarship. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/CTM2017-84763-C3-1-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | glass eel | es_ES |
dc.subject | contaminants of emerging concern | es_ES |
dc.subject | bioconcentration | es_ES |
dc.subject | biotransformation | es_ES |
dc.subject | suspect screening | es_ES |
dc.subject | HPLC-HRMS | es_ES |
dc.title | Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France) | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | /© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-
nc/4.0/) | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0269749122012301?via%3Dihub | es_ES |
dc.identifier.doi | 10.1016/j.envpol.2022.120016 | |
dc.departamentoes | Química Orgánica e Inorgánica | es_ES |
dc.departamentoes | Química analítica | es_ES |
dc.departamentoeu | Kimika Organikoa eta Ez-Organikoa | es_ES |
dc.departamentoeu | Kimika analitikoa | es_ES |