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Fluctuation and change of serum urate levels and flares in gout: results from the NOR-Gout study

dc.contributor.authorUhlig, Till
dc.contributor.authorKaroliussen, Lars F.
dc.contributor.authorSexton, Joe
dc.contributor.authorKvien, Tore K.
dc.contributor.authorHaavardsholm, Espen A.
dc.contributor.authorPérez Ruiz, Fernando
dc.contributor.authorBerner Hammer, Hilde
dc.date.accessioned2022-12-02T18:45:36Z
dc.date.available2022-12-02T18:45:36Z
dc.date.issued2022
dc.identifier.citationClinical Rheumatology 41 : 3817-3823 (2022)es_ES
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.urihttp://hdl.handle.net/10810/58663
dc.description.abstractA gout attack may evolve after a purine-rich diet or alcohol and after starting urate-lowering therapy (ULT). The relationships between fluctuation and change in serum urate (SU) with the occurrence of flares were investigated in this study. In the prospective NOR-Gout study, gout patients with increased SU and a recent flare were treated to target with ULT over 1 year, with follow-up at year 2 with SU and flare as outcomes. SU and flares were assessed at both monthly and 3-monthly intervals until target SU was reached. Fluctuation over periods and changes in SU between two time points were assessed and compared in patients with and without flares. At year 1, 186 patients completed follow-up (88.2%) and 173 (82.0%) at year 2. Mean age (SD) at baseline was 56.4 (13.7) years, disease duration was 7.8 (7.6) years, and 95.3% were men. The first-year SU fluctuation and change were related to flare occurrence during year 1 (both p < 0.05). High fluctuation with an absolute sum of all SU changes during the first 9 months was related to flares over 3-month periods (all p < 0.05), and high fluctuation during the first 3 months was related to flares in months 3-6 (p = 0.04). Monthly and high SU changes or again reaching higher SU levels > 360 mu mol/l were not related to flares. Fluctuation and change in SU were related to flare occurrence during the first year of ULT, while changes between visits and reaching SU levels > 360 mu mol/L were not related to flares.es_ES
dc.description.sponsorshipOpen access funding provided by University of Oslo (incl Oslo University Hospital).es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectflarees_ES
dc.subjectfluctuationes_ES
dc.subjectgoutes_ES
dc.subjectserum uratees_ES
dc.subjecttreat to targetes_ES
dc.subjecturate-lowering treatmentes_ES
dc.titleFluctuation and change of serum urate levels and flares in gout: results from the NOR-Gout studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© The Author(s) 2022. his article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Com- mons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s10067-022-06416-4es_ES
dc.identifier.doi10.1007/s10067-022-06416-4
dc.departamentoesMedicinaes_ES
dc.departamentoeuMedikuntzaes_ES


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© The Author(s) 2022. his article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Com- mons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's license is described as © The Author(s) 2022. his article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Com- mons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.