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The Endocannabinoid System as a Target for Neuroprotection/Neuroregeneration in Perinatal Hypoxic–Ischemic Brain Injury
dc.contributor.author | Duranti, Andrea | |
dc.contributor.author | Beldarrain González, Gorane | |
dc.contributor.author | Álvarez Díaz, Antonia Ángeles | |
dc.contributor.author | Sbriscia, Matilde | |
dc.contributor.author | Carloni, Silvia | |
dc.contributor.author | Balduini, Walter | |
dc.contributor.author | Alonso-Alconada, Daniel | |
dc.date.accessioned | 2023-01-24T16:09:46Z | |
dc.date.available | 2023-01-24T16:09:46Z | |
dc.date.issued | 2022-12-22 | |
dc.identifier.citation | Biomedicines 11(1) : (2023) // Article ID 28 | es_ES |
dc.identifier.issn | 2227-9059 | |
dc.identifier.uri | http://hdl.handle.net/10810/59449 | |
dc.description.abstract | The endocannabinoid (EC) system is a complex cell-signaling system that participates in a vast number of biological processes since the prenatal period, including the development of the nervous system, brain plasticity, and circuit repair. This neuromodulatory system is also involved in the response to endogenous and environmental insults, being of special relevance in the prevention and/or treatment of vascular disorders, such as stroke and neuroprotection after neonatal brain injury. Perinatal hypoxia–ischemia leading to neonatal encephalopathy is a devastating condition with no therapeutic approach apart from moderate hypothermia, which is effective only in some cases. This overview, therefore, gives a current description of the main components of the EC system (including cannabinoid receptors, ligands, and related enzymes), to later analyze the EC system as a target for neonatal neuroprotection with a special focus on its neurogenic potential after hypoxic–ischemic brain injury. | es_ES |
dc.description.sponsorship | EITB Maratoia-BIOEF (BIO18/IC/003), the Spanish Ministry of Science and Innovation: (MINECOR20/P66/AEI/10.13039/501100011033). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | endocannabinoid system | es_ES |
dc.subject | cannabinoid receptors | es_ES |
dc.subject | FAAH inhibitors | es_ES |
dc.subject | MGL inhibitors | es_ES |
dc.subject | neonatal brain injury | es_ES |
dc.subject | hypoxia–ischemia | es_ES |
dc.subject | neuroprotection | es_ES |
dc.subject | neurogenesis | es_ES |
dc.title | The Endocannabinoid System as a Target for Neuroprotection/Neuroregeneration in Perinatal Hypoxic–Ischemic Brain Injury | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2023-01-20T14:22:51Z | |
dc.rights.holder | © 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2227-9059/11/1/28 | es_ES |
dc.identifier.doi | 10.3390/biomedicines11010028 | |
dc.departamentoes | Biología celular e histología | |
dc.departamentoeu | Zelulen biologia eta histologia |
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Bestelakorik adierazi ezean, itemaren baimena horrela deskribatzen da:© 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).