Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions
dc.contributor.author | Trejo, Ángela | |
dc.contributor.author | Masdeu Margalef, Carme | |
dc.contributor.author | Serrano Pérez, Irene | |
dc.contributor.author | Pedrola, Marina | |
dc.contributor.author | Juanola, Narcís | |
dc.contributor.author | Ghashghaei, Ouldouz | |
dc.contributor.author | Jiménez Galisteo, Guadalupe | |
dc.contributor.author | Lavilla, Rodolfo | |
dc.contributor.author | Palacios Gambra, Francisco Javier | |
dc.contributor.author | Alonso Pérez, Concepción Estibaliz | |
dc.contributor.author | Viñas, Miguel | |
dc.date.accessioned | 2023-01-24T17:05:42Z | |
dc.date.available | 2023-01-24T17:05:42Z | |
dc.date.issued | 2023-01-03 | |
dc.identifier.citation | Antibiotics 12(1) : (2023) // Article ID 83 | es_ES |
dc.identifier.issn | 2079-6382 | |
dc.identifier.uri | http://hdl.handle.net/10810/59456 | |
dc.description.abstract | New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiological guidance for medicinal chemistry is a powerful tool to design new and effective antimicrobials. In this case, the readily synthesized compounds open new possibilities in the search for antimicrobials active on mycolic acid-containing bacteria. | es_ES |
dc.description.sponsorship | The work was funded in part by the Marató TV3 Foundation 2018 (#20183530), the National Research Foundation (NRF) (Blue Sky’s Research Programme # 120386), the Ministerio de Ciencia e Innovación, the Spain and European Regional Development Fund (EDFR) (PID2019-107991RB-I00, and PID2021-122558OB-I00, UE) and by Gobierno Vasco, Universidad del País Vasco (GV, IT1701-22; UPV). Technical and human support provided by SGIker (UPV/EHU) is also acknowledged. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-107991RB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2021-122558OB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | antibiotics | es_ES |
dc.subject | drugs | es_ES |
dc.subject | multicomponent reactions | es_ES |
dc.subject | mycobacteria | es_ES |
dc.subject | resistant bacteria | es_ES |
dc.title | Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2023-01-20T14:22:39Z | |
dc.rights.holder | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2079-6382/12/1/83 | es_ES |
dc.identifier.doi | 10.3390/antibiotics12010083 | |
dc.departamentoes | Química orgánica I | |
dc.departamentoeu | Kimika organikoa I |
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Except where otherwise noted, this item's license is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).