Understanding gut-liver axis nitrogen metabolism in Fatty Liver Disease
dc.contributor.author | Cardoso Delgado, Teresa de Jesús | |
dc.contributor.author | De las Heras Montero, Javier Adolfo | |
dc.contributor.author | Martínez Chantar, María Luz ![]() | |
dc.date.accessioned | 2023-01-31T17:54:20Z | |
dc.date.available | 2023-01-31T17:54:20Z | |
dc.date.issued | 2022-12 | |
dc.identifier.citation | Frontiers in Endocrinology 13 : (2022) // Article ID 1058101 | es_ES |
dc.identifier.issn | 1664-2392 | |
dc.identifier.uri | http://hdl.handle.net/10810/59584 | |
dc.description.abstract | The homeostasis of the most important nitrogen-containing intermediates, ammonia and glutamine, is a tightly regulated process in which the gut-liver axis plays a central role. Several studies revealed that nitrogen metabolism is altered in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD), a consensus-driven novel nomenclature for Non-Alcoholic Fatty Liver Disease (NAFLD), the most common chronic liver disease worldwide. Both increased ammonia production by gut microbiota and decreased ammonia hepatic removal due to impaired hepatic urea cycle activity or disrupted glutamine synthetase activity may contribute to hepatic ammonia accumulation underlying steatosis, which can eventually progress to hyperammonemia in more advanced stages of steatohepatitis and overt liver fibrosis. Furthermore, our group recently showed that augmented hepatic ammoniagenesis via increased glutaminase activity and overexpression of the high activity glutaminase 1 isoenzyme occurs in Fatty Liver Disease. Overall, the improved knowledge of disrupted nitrogen metabolism and metabolic miscommunication between the gut and the liver suggests that the reestablishment of altered gut-liver axis nitrogenous balance is an appealing and attractive therapeutic approach to tackle Fatty Liver Disease, a growing and unmet health problem. | es_ES |
dc.description.sponsorship | This work was supported by grants from Ministerio de Ciencia, Innovacion y Universidades (MICINN) PID2020-117116RB-I00 integrated in Plan Estatal de Investigacion Cientifica y Tecnica y Innovacion (to MLM-C), and co-funded with Fondos FEDER (to MLM-C), Subprograma Retos Colaboracion RTC2019-007125-1 (to MLM-C), La Caixa Foundation Program HR17-00601 (to MLM-C), Proyectos Investigacion en Salud DTS20/00138 (to MLM-C), Departamento de Industria del Gobierno Vasco (to MLM-C), and Ciberehd_ISCIII_MINECO, which is funded by the Instituto de Salud Carlos III. This work was partially funded by the Basque Department of Education (IT1281-19) (JdH), "Investigador AECC" (INVES18050CARD) and Ayuda RYC2020-029316-I financiada por MCIN/AEI/10.13039/501100011033 y por El FSE invierte en tu futuro (to TCD). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-117116RB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/RTC2019-007125-1 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/RYC2020-029316-I | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | gut-liver axis | es_ES |
dc.subject | nitrogen metabolism | es_ES |
dc.subject | fatty liver disease | es_ES |
dc.subject | ammonia | es_ES |
dc.subject | glutamine | es_ES |
dc.subject | glutaminase | es_ES |
dc.subject | urea cycle | es_ES |
dc.title | Understanding gut-liver axis nitrogen metabolism in Fatty Liver Disease | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 Delgado, de las Heras and Martínez-Chantar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fendo.2022.1058101/full | es_ES |
dc.identifier.doi | 10.3389/fendo.2022.1058101 | |
dc.departamentoes | Pediatría | es_ES |
dc.departamentoeu | Pediatria | es_ES |
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Except where otherwise noted, this item's license is described as © 2022 Delgado, de las Heras and Martínez-Chantar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.