The effect of early life events on glucose levels in first-episode psychosis
dc.contributor.author | García Rizo, Clemente | |
dc.contributor.author | Cabrera, Bibiana | |
dc.contributor.author | Bioque, Miquel | |
dc.contributor.author | Mezquida, Gisela | |
dc.contributor.author | Lobo, Antonio | |
dc.contributor.author | González Pinto Arrillaga, Ana María | |
dc.contributor.author | Díaz Caneja, Covadonga | |
dc.contributor.author | Corripio, Iluminada | |
dc.contributor.author | Vieta, Eduard | |
dc.contributor.author | Baeza, Immaculada | |
dc.contributor.author | García Portilla, María Paz | |
dc.contributor.author | Gutiérrez Fraile, Miguel | |
dc.contributor.author | Rodríguez Jiménez, Roberto | |
dc.contributor.author | Garriga, Marina | |
dc.contributor.author | Fernández Egea, Emilio | |
dc.contributor.author | Bernardo, Miguel | |
dc.contributor.author | PEPs Group | |
dc.date.accessioned | 2023-02-08T15:00:00Z | |
dc.date.available | 2023-02-08T15:00:00Z | |
dc.date.issued | 2022-12 | |
dc.identifier.citation | Frontiers in Endocrinology 13 : (2022) // Article ID 983792 | es_ES |
dc.identifier.issn | 1664-2392 | |
dc.identifier.uri | http://hdl.handle.net/10810/59725 | |
dc.description.abstract | First episode of psychosis (FEP) patients display a wide variety of metabolic disturbances at onset, which might underlie these patients’ increased morbidity and early mortality. Glycemic abnormalities have been previously related to pharmacological agents; however, recent research highlights the impact of early life events. Birth weight (BW), an indirect marker of the fetal environment, has been related to glucose abnormalities in the general population over time. We aim to evaluate if BW correlates with glucose values in a sample of FEP patients treated with different antipsychotics. Two hundred and thirty-six patients were included and evaluated for clinical and metabolic variables at baseline and at 2, 6, 12, and 24 months of follow-up. Pearson correlations and linear mixed model analysis were conducted to analyze the data. Antipsychotic treatment was grouped due to its metabolic risk profile. In our sample of FEP patients, BW was negatively correlated with glucose values at 24 months of follow-up [r=-0.167, p=0.037]. BW showed a trend towards significance in the association with glucose values over the 24-month period (F=3.22; p=0.073) despite other confounders such as age, time, sex, body mass index, antipsychotic type, and chlorpromazine dosage. This finding suggests that BW is involved in the evolution of glucose values over time in a cohort of patients with an FEP, independently of the type of pharmacological agent used in treatment. Our results highlight the importance of early life events in the later metabolic outcome of patients. | es_ES |
dc.description.sponsorship | This study is part of a coordinated-multicentre Project, funded by the Ministerio de Economía y Competitividad (PI08/0208; PI11/00325; PI14/00612), Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional. Unión Europea. Una manera de hacer Europa, Centro de Investigación Biomédica en Red de salud Mental, CIBERSAM, by the CERCA Programme/Generalitat de Catalunya and Secretaria d’Universitats i Recerca del Departament d’Economia I Coneixement (2017SGR1355). This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project “PI20/00661” and co-funded by the European Union. This work was developed (in part) at the Centro Esther Koplowitz (Barcelona). This project is also grateful for the support of the Institut de Neurociències, Universitat de Barcelona. This research was supported by CIBER -Consorcio Centro de Investigación Biomédica en Red- (código CIBER), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – European Regional Development Fund. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | first-episode psychosis | es_ES |
dc.subject | glucose values | es_ES |
dc.subject | birth weight | es_ES |
dc.subject | fetal programming | es_ES |
dc.subject | thrifty psychiatric phenotype | es_ES |
dc.title | The effect of early life events on glucose levels in first-episode psychosis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 Garcia-Rizo, Cabrera, Bioque, Mezquida, Lobo, Gonzalez-Pinto, Diaz-Caneja, Corripio, Vieta, Baeza, Garcia-Portilla, Gutierrez-Fraile, Rodriguez-Jimenez, Garriga, Fernandez-Egea, Bernardo and PEPs GROUP. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fendo.2022.983792/full | es_ES |
dc.identifier.doi | 10.3389/fendo.2022.983792 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as © 2022 Garcia-Rizo, Cabrera, Bioque, Mezquida, Lobo, Gonzalez-Pinto, Diaz-Caneja, Corripio, Vieta, Baeza, Garcia-Portilla, Gutierrez-Fraile, Rodriguez-Jimenez, Garriga, Fernandez-Egea, Bernardo and PEPs GROUP. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.