Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug
dc.contributor.author | Ugalde Arbizu, Maider | |
dc.contributor.author | Aguilera-Correa, John Jairo ![]() | |
dc.contributor.author | García Almodóvar, Victoria | |
dc.contributor.author | Ovejero Paredes, Karina | |
dc.contributor.author | Díaz García, Diana | |
dc.contributor.author | Esteban, Jaime ![]() | |
dc.contributor.author | Páez, Paulina L. | |
dc.contributor.author | Prashar, Sanjiv | |
dc.contributor.author | San Sebastian, Eider ![]() | |
dc.contributor.author | Filice, Marco | |
dc.contributor.author | Gómez Ruiz, Santiago ![]() | |
dc.date.accessioned | 2023-02-27T16:31:46Z | |
dc.date.available | 2023-02-27T16:31:46Z | |
dc.date.issued | 2023-02-07 | |
dc.identifier.citation | Pharmaceutics 15(2) : (2023) // Article ID 560 | es_ES |
dc.identifier.issn | 1999-4923 | |
dc.identifier.uri | http://hdl.handle.net/10810/60131 | |
dc.description.abstract | Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and a minimum content of an organotin(IV) fragment (1-MSN-Sn, 2-MSN-Sn, 2-SBA-Sn, 2-FSPm-Sn and 2-FSPs-Sn), were identified as excellent anticancer agents against triple negative breast cancer, one of the most diagnosed and aggressive cancerous tumors, with very poor prognosis. Notably, compound 2-MSN-Sn shows selectivity for cancer cells and excellent luminescent properties detectable by imaging techniques once internalized. The same compound is also able to interact with and nearly eradicate biofilms of Staphylococcus aureus, the most common bacteria isolated from chronic wounds and burns, whose treatment is a clinical challenge. 2-MSN-Sn is efficiently internalized by bacteria in a biofilm state and destroys the latter through reactive oxygen species (ROS) generation. Its internalization by bacteria was also efficiently monitored by fluorescence imaging. Since silica nanoparticles are particularly suitable for oral or topical administration, and considering both its anticancer and antibacterial activity, 2-MSN-Sn represents a new dual-condition theranostic agent, based primarily on natural products or their derivatives and with only a minimum amount of a novel metallodrug. | es_ES |
dc.description.sponsorship | We would like to thank funding from RTI2018-094322-B-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”, by the “European Union” and the University of the Basque Country UPV/EHU (GIC18/143). M.F. is grateful to Instituto de Salud Carlos III (ISCIII) for project No DTS20/00109 (AES20-ISCIII) and PI22/00789 (AES22-ISCIII). M.F. and K.O.P. acknowledge the support of Microscopy & Dynamic Imaging Unit of CNIC, Madrid, Spain. The Unit is part of the ReDiB-ICTS and has the support of FEDER, “Una manera de hacer Europa.” The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/CEX2020-001041-S | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RTI2018-094322-B-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | cancer | es_ES |
dc.subject | bacteria | es_ES |
dc.subject | biofilm | es_ES |
dc.subject | oral | es_ES |
dc.subject | topical | es_ES |
dc.subject | luminescence | es_ES |
dc.subject | theranosis | es_ES |
dc.subject | S. aureus | es_ES |
dc.subject | wound healing | es_ES |
dc.title | Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2023-02-24T14:08:33Z | |
dc.rights.holder | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/15/2/560 | es_ES |
dc.identifier.doi | 10.3390/pharmaceutics15020560 | |
dc.departamentoes | Química aplicada | |
dc.departamentoeu | Kimika aplikatua |
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Except where otherwise noted, this item's license is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).