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Palladium-Catalyzed Site-Selective C(sp2)−H Acetoxylation of Tyrosine-Containing Peptides

dc.contributor.authorUrruzuno Guiu, Iñaki
dc.contributor.authorAndrade Sampedro, Paula
dc.contributor.authorCorrea Navarro, Arkaitz ORCID
dc.date.accessioned2023-03-06T17:33:30Z
dc.date.available2023-03-06T17:33:30Z
dc.date.issued2023-02
dc.identifier.citationEuropean Journal of Organic Chemistry 26(6) : (2023) // Article ID e202201489es_ES
dc.identifier.issn1434-193X
dc.identifier.issn1099-0690
dc.identifier.urihttp://hdl.handle.net/10810/60284
dc.description.abstractA Pd-catalyzed C(sp2)−H acetoxylation of Tyr-containing peptides is described. The method relies on the use of a removable 2-pyridyloxy group as directing group and is distinguished by its reliable scalability and easily tuned regioselectivity to perform mono- and diacetoxylation reactions. Remarkably, the assembly of L–DOPA peptidomimetics is beyond reach upon cleavage of the directing group.es_ES
dc.description.sponsorshipWe are grateful to Ministerio de Ciencia e Innovación (RTI2018-093721-B-I00, MCI/AEI/FEDER, UE) and Basque Government (IT-1741-22) for financial support. We thank for the technical and human support provided by Central Service of Analysis-SGIker of UPV/EHU and European funding (ERDF and ESF).es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relationinfo:eu-repo/grantAgreement/MICIU/RTI2018-093721-B-I00es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectacetoxylationes_ES
dc.subjectamino acides_ES
dc.subjectC-H functionalizationes_ES
dc.subjectpalladium catalysises_ES
dc.subjectpeptideses_ES
dc.titlePalladium-Catalyzed Site-Selective C(sp2)−H Acetoxylation of Tyrosine-Containing Peptideses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2022 The Authors. European Journal of Organic Chemistry published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.es_ES
dc.rights.holderAtribución-NoComercial-SinDerivadas 3.0 España*
dc.relation.publisherversionhttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202201489es_ES
dc.identifier.doi10.1002/ejoc.202201489
dc.departamentoesQuímica orgánica Ies_ES
dc.departamentoeuKimika organikoa Ies_ES


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© 2022 The Authors. European Journal of Organic Chemistry published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as © 2022 The Authors. European Journal of Organic Chemistry published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.