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dc.contributor.authorSardón Prado, Olaia
dc.contributor.authorSysPharmPediA consortium
dc.date.accessioned2023-03-20T14:59:44Z
dc.date.available2023-03-20T14:59:44Z
dc.date.issued2023-02
dc.identifier.citationPediatric Allergy and Immunology 34(2) : (2023) // Article ID e13919es_ES
dc.identifier.issn0905-6157
dc.identifier.issn1399-3038
dc.identifier.urihttp://hdl.handle.net/10810/60414
dc.description.abstractBackground Uncontrolled asthma can lead to severe exacerbations and reduced quality of life. Research has shown that the microbiome may be linked with asthma characteristics; however, its association with asthma control has not been explored. We aimed to investigate whether the gastrointestinal microbiome can be used to discriminate between uncontrolled and controlled asthma in children. Methods 143 and 103 feces samples were obtained from 143 children with moderate-to-severe asthma aged 6 to 17 years from the SysPharmPediA study. Patients were classified as controlled or uncontrolled asthmatics, and their microbiome at species level was compared using global (alpha/beta) diversity, conventional differential abundance analysis (DAA, analysis of compositions of microbiomes with bias correction), and machine learning [Recursive Ensemble Feature Selection (REFS)]. Results Global diversity and DAA did not find significant differences between controlled and uncontrolled pediatric asthmatics. REFS detected a set of taxa, including Haemophilus and Veillonella, differentiating uncontrolled and controlled asthma with an average classification accuracy of 81% (saliva) and 86% (feces). These taxa showed enrichment in taxa previously associated with inflammatory diseases for both sampling compartments, and with COPD for the saliva samples. Conclusion Controlled and uncontrolled children with asthma can be differentiated based on their gastrointestinal microbiome using machine learning, specifically REFS. Our results show an association between asthma control and the gastrointestinal microbiome. This suggests that the gastrointestinal microbiome may be a potential biomarker for treatment responsiveness and thereby help to improve asthma control in children.es_ES
dc.description.sponsorshipThe SysPharmPediA consortium is supported by ZonMW [project number: 9003035001], the Ministry of Education, Science, and Sport of the Republic of Slovenia [contract number C330-16-500106]; the German Ministry of Education and Research (BMBF) [project number FKZ 031 L0088]; Instituto de Salud Carlos III (ISCIII) through Strategic Action for Health Research (AES) and European Community (EC) within the Active and Assisted Living (AAL) Program framework [award numbers AC15/00015 and AC15/00058] under the frame of the ERACoSysMed JTC-1 Call. M.P.-Y. was funded by the Ramón y Cajal Program (RYC-2015-17205) by the Spanish Ministry of Science and Innovation (MICINN), the State Research Agency, and the European Regional Development Fund from the European Union (MICINN/AEI/FEDER, UE, grant SAF2017-83417R). U.P. and M.G. were funded by Slovenian Research Agency (research core funding No. P3-0067). M.I.A.-A. was funded by the Egyptian Government Ph.D. Scholarships.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/RYC-2015-17205es_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/SAF2017-83417Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/es/*
dc.subjectasthmaes_ES
dc.subjectdesease managementes_ES
dc.subjecttreatmentes_ES
dc.titleClassifying asthma control using salivary and fecal bacterial microbiome in children with moderate-to-severe asthmaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2023 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.es_ES
dc.rights.holderAtribución-NoComercial 3.0 España*
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/pai.13919es_ES
dc.identifier.doi10.1111/pai.13919
dc.departamentoesPediatríaes_ES
dc.departamentoeuPediatriaes_ES


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© 2023 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Except where otherwise noted, this item's license is described as © 2023 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.