Genetic regulation of body size and morphology in children: a twin study of 22 anthropometric traits
dc.contributor.author | Silventoinen, Karri | |
dc.contributor.author | Maia, José Antonio | |
dc.contributor.author | Li, Weilong | |
dc.contributor.author | Sund, Reijo | |
dc.contributor.author | Gouveia, Elvio | |
dc.contributor.author | Antunes, Antonio | |
dc.contributor.author | Marques, Gonçalo | |
dc.contributor.author | Thomis, Martine | |
dc.contributor.author | Jelenkovic Moreno, Aline | |
dc.contributor.author | Kaprio, Jaakko | |
dc.contributor.author | Freitas, Duarte L. | |
dc.date.accessioned | 2023-03-23T14:30:19Z | |
dc.date.available | 2023-03-23T14:30:19Z | |
dc.date.issued | 2023-03 | |
dc.identifier.citation | International Journal of Obesity 47(3) : 181-189 (2023) | es_ES |
dc.identifier.issn | 0307-0565 | |
dc.identifier.issn | 1476-5497 | |
dc.identifier.uri | http://hdl.handle.net/10810/60466 | |
dc.description.abstract | Background Anthropometric measures show high heritability, and genetic correlations have been found between obesity-related traits. However, we lack a comprehensive analysis of the genetic background of human body morphology using detailed anthropometric measures. Methods Height, weight, 7 skinfold thicknesses, 7 body circumferences and 4 body diameters (skeletal breaths) were measured in 214 pairs of twin children aged 3–18 years (87 monozygotic pairs) in the Autonomous Region of Madeira, Portugal. Factor analysis (Varimax rotation) was used to analyze the underlying structure of body physique. Genetic twin modeling was used to estimate genetic and environmental contributions to the variation and co-variation of the anthropometric traits. Results Together, two factors explained 80% of the variation of all 22 anthropometric traits in boys and 73% in girls. Obesity measures (body mass index, skinfold thickness measures, as well as waist and hip circumferences) and limb circumferences loaded most strongly on the first factor, whereas height and body diameters loaded especially on the second factor. These factors as well as all anthropometric measures showed high heritability (80% or more for most of the traits), whereas the rest of the variation was explained by environmental factors not shared by co-twins. Obesity measures showed high genetic correlations (0.75–0.98). Height showed the highest genetic correlations with body diameter measures (0.58–0.76). Correlations between environmental factors not shared by co-twins were weaker than the genetic correlations but still substantial. The correlation patterns were roughly similar in boys and girls. Conclusions Our results show high genetic correlations underlying the human body physique, suggesting that there are sets of genes widely affecting anthropometric traits. Better knowledge of these genetic variants can help to understand the development of obesity and other features of the human physique. | es_ES |
dc.description.sponsorship | The project “Genetic and environmental influences on physical activity, fitness and health: the Madeira family study” was supported by FCT - Fundação para a Ciência e a Tecnologia (The Portuguese National Funding Agency for Science, Research and Technology), reference POCI/DES/56834/2004. Open Access funding provided by University of Helsinki including Helsinki University Central Hospital. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.title | Genetic regulation of body size and morphology in children: a twin study of 22 anthropometric traits | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http:// creativecommons.org/licenses/by/4.0/ | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.nature.com/articles/s41366-023-01253-0 | es_ES |
dc.identifier.doi | 10.1038/s41366-023-01253-0 | |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |
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