Validation of UVEDAI: An Index for Evaluating the Level of Inflammatory Activity in Uveitis
dc.contributor.author | Pato Cour, Esperanza | |
dc.contributor.author | Martín Martínez, Auxiliadora | |
dc.contributor.author | Borrego Sanz, Lara | |
dc.contributor.author | Martínez Costa, Lucía | |
dc.contributor.author | Esteban Ortega, Mar | |
dc.contributor.author | Sánchez Costa, Jesús T. | |
dc.contributor.author | Cordero Coma, Miguel | |
dc.contributor.author | Fonollosa Calduch, Alejandro | |
dc.contributor.author | Díaz Valle, Teresa | |
dc.contributor.author | Rodríguez González, Fayna | |
dc.contributor.author | Sainz de la Mata, Maite | |
dc.contributor.author | Díaz Valle, David | |
dc.contributor.author | González Ocampo, Samuel | |
dc.contributor.author | López Sierra, Sara | |
dc.contributor.author | García Lozano, Isabel | |
dc.contributor.author | Garzo García, Irene | |
dc.contributor.author | Artaraz Beobide, Joseba Iñaki | |
dc.contributor.author | Gurrea Almela, María | |
dc.contributor.author | Tejera, Marta | |
dc.contributor.author | Moll Udina, Aina | |
dc.contributor.author | Valls Pascual, Elia | |
dc.contributor.author | Muñoz Fernández, Santiago | |
dc.contributor.author | Méndez Fernández, Rosalía | |
dc.date.accessioned | 2023-03-23T16:21:53Z | |
dc.date.available | 2023-03-23T16:21:53Z | |
dc.date.issued | 2023-04 | |
dc.identifier.citation | Ophthalmology and Therapy 12(2) : 1045-1055 (2023) | es_ES |
dc.identifier.issn | 2193-8245 | |
dc.identifier.issn | 2193-6528 | |
dc.identifier.uri | http://hdl.handle.net/10810/60469 | |
dc.description.abstract | Introduction Uveitis is the inflammation of the middle layer of the eye, the uvea, and is a major cause of blindness. None of the instruments used in clinical practice are, in themselves, sufficient to evaluate the course of uveitis. Therefore, it is necessary to develop instruments enabling standardized measurement of inflammatory activity. We developed a composite disease activity index for patients with uveitis known as UVEDAI, which considers the overall activity of the eye. The objective of this study was to validate the composite index of ocular inflammation, UVEDAI. Methods A multicenter cross-sectional study involving eight Spanish tertiary hospitals. Sixty-two patients aged ≥ 18 years with acute uveitis were recruited. Participants gave informed consent before participating in the study. A full ophthalmological examination was performed by two ophthalmologists to determine inflammatory activity: one used the UVEDAI score and the other used clinical judgment. The ophthalmologists did not share their findings with each other to avoid introducing bias into the analysis. Construct validity was established by means of factor analysis. The criterion validity of the index was determined using an ordinal multivariate regression model, in which the dependent variable was the degree of uveal inflammation (mild, moderate, or high/severe). Cut-off points were determined for the UVEDAI and for the receiver operating characteristic (ROC) curves. Results Sixty-two patients were included. Total variance with the three components accounted for 80.32% of the construct validity. Each of the three components identified one type of eye involvement. The discriminatory capacity of UVEDAI was 0.867 (95% CI 0.778; 0.955 p < 0.001) for mild versus moderate–high and 0.946 (95% CI 0.879; 1.000 p < 0.001) for high versus mild–moderate. Conclusions The variables included in UVEDAI enable ocular inflammatory activity to be described with a high degree of accuracy. The index may be used to evaluate and classify this activity with considerable discriminatory power. | es_ES |
dc.description.sponsorship | We would like to acknowledge the support of Abbvie: this study was conducted with an unrestricted grant from Abbvie. The Spanish Society of Rheumatology is the sponser and funder of this study and the journal's Rapid Service Fee, and has participated in the study design; in the analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. The corresponding author had full access to all study data and had final responsibility for the decision to submit the manuscript for publication. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | uveitis | es_ES |
dc.subject | composite index | es_ES |
dc.subject | ocular inflammation | es_ES |
dc.subject | construct validity | es_ES |
dc.subject | criterion validity | es_ES |
dc.subject | UVEDAI | es_ES |
dc.title | Validation of UVEDAI: An Index for Evaluating the Level of Inflammatory Activity in Uveitis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2023, corrected publication 2023. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/. | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s40123-023-00654-8 | es_ES |
dc.identifier.doi | 10.1007/s40123-023-00654-8 | |
dc.departamentoes | Dermatología, oftalmología y otorrinolaringología | es_ES |
dc.departamentoeu | Dermatologia, oftalmologia eta otorrinolaringologia | es_ES |
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Except where otherwise noted, this item's license is described as © The Author(s) 2023, corrected publication 2023. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.