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dc.contributor.authorVera Salas, Silvia
dc.contributor.authorLanda Álvarez, Aitor
dc.contributor.authorMielgo Vicente, María Antonia ORCID
dc.contributor.authorGamboa Landa, José Ignacio
dc.contributor.authorOyarbide Garmendia, Juan Miguel ORCID
dc.contributor.authorSoloshonok, Vadym Anatolievch ORCID
dc.date.accessioned2023-03-29T13:47:53Z
dc.date.available2023-03-29T13:47:53Z
dc.date.issued2023-03-16
dc.identifier.citationMolecules 28(6) : (2023) // Article ID 2694es_ES
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10810/60550
dc.description.abstractAldehydes constitute a main class of organic compounds widely applied in synthesis. As such, catalyst-controlled enantioselective α-functionalization of aldehydes has attracted great interest over the years. In this context, α-branched aldehydes are especially challenging substrates because of reactivity and selectivity issues. Firstly, the transient trisubstituted enamines and enolates resulting upon treatment with an aminocatalyst or a base, respectively, would exhibit attenuated reactivity; secondly, mixtures of E- and Z-configured enamines/enolates may be formed; and third, effective face-discrimination on such trisubstituted sp2 carbon intermediates by the incoming electrophilic reagent is not trivial. Despite these issues, in the last 15 years, several catalytic approaches for the α-functionalization of prostereogenic α-branched aldehydes that proceed in useful yields and diastereo- and enantioselectivity have been uncovered. Developments include both organocatalytic and metal-catalyzed approaches as well as dual catalysis strategies for forging new carbon–carbon and carbon–heteroatom (C-O, N, S, F, Cl, Br, …) bond formation at Cα of the starting aldehyde. In this review, some key early contributions to the field are presented, but focus is on the most recent methods, mainly covering the literature from year 2014 onward.es_ES
dc.description.sponsorshipThis research was funded by Basque Government (grant IT-1583-22) and by MCIN/AEI/10.13039/501100011033 (grant PID2019-109633GB-C21).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2019-109633GB-C21es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectaldehydeses_ES
dc.subjectasymmetric catalysises_ES
dc.subjectquaternary carbones_ES
dc.subjectorganocatalysises_ES
dc.subjectdual catalysises_ES
dc.subjectreaction umpolunges_ES
dc.titleCatalytic Asymmetric α-Functionalization of α-Branched Aldehydeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2023-03-28T12:56:43Z
dc.rights.holder© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).es_ES
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/28/6/2694es_ES
dc.identifier.doi10.3390/molecules28062694
dc.departamentoesQuímica orgánica I
dc.departamentoeuKimika organikoa I


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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).
Except where otherwise noted, this item's license is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).