Melanoma and Nevi Subtype Histopathological Characterization with Optical Coherence Tomography
dc.contributor.author | Saratxaga, Cristina L. | |
dc.contributor.author | Asumendi Mallea, Aintzane | |
dc.contributor.author | Gardeazabal García, Jesús | |
dc.contributor.author | Izu Belloso, Rosa María | |
dc.contributor.author | Sánchez Díez, Ana | |
dc.contributor.author | Cancho Galán, Goikoane | |
dc.contributor.author | Morales González, María Celia | |
dc.contributor.author | Lage, Sergio | |
dc.contributor.author | Boyano López, María Dolores | |
dc.contributor.author | Conde, Olga M. | |
dc.contributor.author | Garrote Contreras, Estíbaliz | |
dc.date.accessioned | 2023-03-30T15:00:08Z | |
dc.date.available | 2023-03-30T15:00:08Z | |
dc.date.issued | 2023-02-23 | |
dc.identifier.citation | Life 13(3) : (2023) // Article ID 625 | es_ES |
dc.identifier.issn | 2075-1729 | |
dc.identifier.uri | http://hdl.handle.net/10810/60572 | |
dc.description.abstract | Background: Melanoma incidence has continued to rise in the latest decades, and the forecast is not optimistic. Non-invasive diagnostic imaging techniques such as optical coherence tomography (OCT) are largely studied; however, there is still no agreement on its use for the diagnosis of melanoma. For dermatologists, the differentiation of non-invasive (junctional nevus, compound nevus, intradermal nevus, and melanoma in-situ) versus invasive (superficial spreading melanoma and nodular melanoma) lesions is the key issue in their daily routine. Methods: This work performs a comparative analysis of OCT images using haematoxylin–eosin (HE) and anatomopathological features identified by a pathologist. Then, optical and textural properties are extracted from OCT images with the aim to identify subtle features that could potentially maximize the usefulness of the imaging technique in the identification of the lesion’s potential invasiveness. Results: Preliminary features reveal differences discriminating melanoma in-situ from superficial spreading melanoma and also between melanoma and nevus subtypes that pose a promising baseline for further research. Conclusions: Answering the final goal of diagnosing non-invasive versus invasive lesions with OCT does not seem feasible in the short term, but the obtained results demonstrate a step forward to achieve this. | es_ES |
dc.description.sponsorship | This work has been funded by the Department of Economic Development, Sustainability and the Environment of the Basque Government (Spain) ELKARTEK projects ONKOTOOLS with grant numbers KK-2020/00069, the Spanish Ministry of Science and Education CERVERA project AI4ES with grant numbers CER-20211030, and by the ECSEL JU European project ASTONISH with the grant number 692470, UC Industrial Doctorate DI14. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/692470 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | skin cancer | es_ES |
dc.subject | melanoma | es_ES |
dc.subject | OCT | es_ES |
dc.subject | HE | es_ES |
dc.subject | optical biopsy | es_ES |
dc.subject | histopathology | es_ES |
dc.subject | optical properties | es_ES |
dc.subject | textural properties | es_ES |
dc.subject | CADx | es_ES |
dc.title | Melanoma and Nevi Subtype Histopathological Characterization with Optical Coherence Tomography | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2023-03-28T12:56:15Z | |
dc.rights.holder | © 2023 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2075-1729/13/3/625 | es_ES |
dc.identifier.doi | 10.3390/life13030625 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Biología celular e histología | |
dc.departamentoes | Dermatología, oftalmología y otorrinolaringología | |
dc.departamentoes | Ingeniería de sistemas y automática | |
dc.departamentoeu | Zelulen biologia eta histologia | |
dc.departamentoeu | Dermatologia, oftalmologia eta otorrinolaringologia | |
dc.departamentoeu | Sistemen ingeniaritza eta automatika |
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Except where otherwise noted, this item's license is described as © 2023 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).