Sensitization to isothiazolinones in the Spanish Contact Dermatitis Registry (REIDAC): 2019–2021 epidemiological situation
dc.contributor.author | Hernández Fernández, Carlos Pelayo | |
dc.contributor.author | Borrego Hernando, Leopoldo | |
dc.contributor.author | Mercader García, Pedro | |
dc.contributor.author | Giménez Arnau, Anna María | |
dc.contributor.author | Sánchez Pérez, Javier | |
dc.contributor.author | Silvestre Salvador, Juan Francisco | |
dc.contributor.author | González Pérez, Ricardo | |
dc.contributor.author | Sanz Sánchez, Tatiana | |
dc.contributor.author | Sánchez Gilo, Araceli | |
dc.contributor.author | Melé Ninot, Gemma | |
dc.contributor.author | Zaragoza Ninet, Violeta | |
dc.contributor.author | Miquel Miquel, Francisco Javier | |
dc.contributor.author | Carrascosa Carrillo, José Manuel | |
dc.contributor.author | Córdoba Guijarro, Susana | |
dc.contributor.author | Gatica Ortega, María Elena | |
dc.contributor.author | Ruiz González, Inmaculada | |
dc.contributor.author | Serra Baldrich, Esther | |
dc.contributor.author | Tous Romero, Fátima | |
dc.contributor.author | Rodríguez Serna, Mercedes | |
dc.contributor.author | Pastor Nieto, María Antonia | |
dc.contributor.author | Pérez Feal, Patricia | |
dc.contributor.author | Hervella Garcés, Marcos | |
dc.contributor.author | De Vega Martínez, Marina | |
dc.contributor.author | García Doval, Ignacio | |
dc.date.accessioned | 2023-05-04T16:58:43Z | |
dc.date.available | 2023-05-04T16:58:43Z | |
dc.date.issued | 2023-03 | |
dc.identifier.citation | Contact Dermatitis 88(3) : 212-219 (2023) | es_ES |
dc.identifier.issn | 0105-1873 | |
dc.identifier.issn | 1600-0536 | |
dc.identifier.uri | http://hdl.handle.net/10810/61037 | |
dc.description.abstract | Background: Current frequency and risk factors for sensitization to methylisothiazolinone (MI), methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in Spain are not well known. Objectives: To study the frequency of sensitization, risk factors and simultaneous sensitization between the four isothiazolinones. Materials and Methods: We analysed all 2019-2021 consecutive patients patch-tested with MI (0.2% aq.), MCI/MI (0.02% aq.), BIT (0.1% pet.) and OIT (0.1% pet) within the Spanish Contact Dermatitis Registry (REIDAC). Results: A total of 2511 patients were analysed. Frequencies of sensitization were: any isothiazolinone 15.7%, MI 6.8%, MCI/MI 4.8%, BIT 3.5% and OIT 0.5%. MI and MCI/MI sensitization was associated with being occupationally active, hand dermatitis, detergents and age over 40. BIT sensitization was associated with leg dermatitis and age over 40. About one in nine MI-positive patients were positive to BIT, whereas one in five BIT-positive patients were positive to MI. Conclusions: Sensitization to MI, MCI/MI and BIT is still common in Spain, while sensitization to OIT is rare. Currently, sensitization to MI and MCI/MI seems to be occupationally related. Although its origin is unknown, sensitization to BIT is more frequent in patients aged over 40 years. Simultaneous sensitization between MI and BIT is uncommon. | es_ES |
dc.description.sponsorship | The Spanish Registry of Contact Dermatitis (REIDAC) is promoted by the Fundación Piel Sana (Academia Española de Dermatología y Venereología), which has received financial support from the Spanish Medicines and Health Products Agency (Agencia Española de Medicamentos y Productos Sanitarios. https://www.boe.es/boe/dias/2022/04/11/pdfs/BOE-A-2022-5975.pdf) and Sanofi. The funders were not involved in the design and conduct of the study, collection, management, analysis and interpretation of data, preparation, review, approval of the manuscript, or decision to submit the manuscript for publication. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | benzisothiazolinone | es_ES |
dc.subject | contact dermatitis | es_ES |
dc.subject | methylchloroisothiazolinone/methylisothiazolinone | es_ES |
dc.subject | methylisothiazolinone | es_ES |
dc.subject | octylisothiazolinone | es_ES |
dc.subject | patch tests | es_ES |
dc.subject | Spain | es_ES |
dc.subject | standard series | es_ES |
dc.title | Sensitization to isothiazolinones in the Spanish Contact Dermatitis Registry (REIDAC): 2019–2021 epidemiological situation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1111/cod.14251 | es_ES |
dc.identifier.doi | 10.1111/cod.14251 | |
dc.departamentoes | Dermatología, oftalmología y otorrinolaringología | es_ES |
dc.departamentoeu | Dermatologia, oftalmologia eta otorrinolaringologia | es_ES |
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Except where otherwise noted, this item's license is described as © 2022 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.