Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies
dc.contributor.author | Chávez Hidalgo, Lourdes Pilar | |
dc.contributor.author | Martín Fernández de Labastida, Silvia | |
dc.contributor.author | Martínez de Pancorbo Gómez, María de los Angeles | |
dc.contributor.author | Arroyo Izaga, Marta | |
dc.date.accessioned | 2023-05-18T17:16:45Z | |
dc.date.available | 2023-05-18T17:16:45Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | World Journal of Gastroenterology 29(7) : 1219-1234 (2023) | es_ES |
dc.identifier.issn | 1007-9327 | |
dc.identifier.issn | 2219-2840 | |
dc.identifier.uri | http://hdl.handle.net/10810/61171 | |
dc.description.abstract | BACKGROUNDDietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). However, whether the influence of methyl donor intake is modified by polymorphisms in such epigenetic regulators is still unclear.AIMTo improve the current understanding of the molecular basis of CRC.METHODSA literature search in the Medline database, Reference Citation Analysis (https:// www.referencecitationanalysis.com/), and manual reference screening were performed to identify observational studies published from inception to May 2022.RESULTSA total of fourteen case-control studies and five cohort studies were identified. These studies included information on dietary methyl donors, dietary components that potentially modulate the bioavailability of methyl groups, genetic variants of methyl metabolizing enzymes, and/or markers of CpG island methylator phenotype and/or microsatellite instability, and their possible interactions on CRC risk.CONCLUSIONSeveral studies have suggested interactions between methylenetetrahydrofolate reductase polymorphisms, methyl donor nutrients (such as folate) and alcohol on CRC risk. Moreover, vitamin B-6, niacin, and alcohol may affect CRC risk through not only genetic but also epigenetic regulation. Identification of specific mechanisms in these interactions associated with CRC may assist in developing targeted prevention strategies for individuals at the highest risk of developing CRC. | es_ES |
dc.description.sponsorship | Supported by The Basque Government (BIOMICs Research Group, MICROFLUIDICs & BIOMICs Cluster of the University of the Basque Country UPV/EHU), No. IT1633-22. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Baishideng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | colorectal cancer | es_ES |
dc.subject | DNA methylation | es_ES |
dc.subject | epigenetics | es_ES |
dc.subject | Methyl donors | es_ES |
dc.subject | microsatellite instability | es_ES |
dc.subject | nutrients | es_ES |
dc.title | Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://www.wjgnet.com/1007-9327/full/v29/i7/1219.htm | es_ES |
dc.identifier.doi | 10.3748/wjg.v29.i7.1219 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | es_ES |
dc.departamentoes | Zoología y biología celular animal | es_ES |
dc.departamentoeu | Farmazia eta elikagaien zientziak | es_ES |
dc.departamentoeu | Zoologia eta animalia zelulen biologia | es_ES |
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Except where otherwise noted, this item's license is described as This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/