The Intramolecular Povarov Tool in the Construction of Fused Nitrogen-Containing Heterocycles
dc.contributor.author | Masdeu Margalef, Carme | |
dc.contributor.author | De los Santos Ruiz, Jesús Manuel | |
dc.contributor.author | Palacios Gambra, Francisco Javier | |
dc.contributor.author | Alonso Pérez, Concepción Estibaliz | |
dc.date.accessioned | 2023-06-29T15:41:27Z | |
dc.date.available | 2023-06-29T15:41:27Z | |
dc.date.issued | 2023-06 | |
dc.identifier.citation | Topics in Current Chemistry 381(4) : (2023) // Article ID 20 | es_ES |
dc.identifier.issn | 2365-0869 | |
dc.identifier.issn | 2364-8961 | |
dc.identifier.uri | http://hdl.handle.net/10810/61799 | |
dc.description.abstract | Nitrogen heterocycles are part of the structure of natural products and agents with important biological activity, such as antiviral, antibiotic, and antitumor drugs. For this reason, heterocyclic compounds are one of today’s most desirable synthetic targets and the Povarov reaction is a powerful synthetic tool for the construction of highly functionalized heterocyclic systems. This process involves an aromatic amine, a carbonyl compound, and an olefin or acetylene to give rise to the formation of a nitrogen-containing heterocycle. This review illustrates advances in the synthetic aspects of the intramolecular Povarov reaction for the construction of intricate nitrogen-containing polyheterocyclic compounds. This original review presents research done in this field, with references to important works by internationally relevant research groups on this current topic, covering the literature from 1992 to 2022. The intramolecular Povarov reactions are described here according to the key processes involved, using different combinations of aromatic or heteroaromatic amines, and aliphatic, aromatic, or heteroaromatic aldehydes. Some catalytic reactions promoted by transition metals are detailed, as well as the oxidative Povarov reaction and some asymmetric intramolecular Povarov processes. | es_ES |
dc.description.sponsorship | Financial support from the Ministerio de Ciencia, Innovación y Universidades (MCIU) (PID2021-122558OB-I00, UE), by Gobierno Vasco, Universidad del País Vasco (GV, IT1701- 22; UPV) and by Fundación Vital (VITAL21/01) is gratefully acknowledged. Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2021-122558OB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Povarov reaction | es_ES |
dc.subject | intramolecular | es_ES |
dc.subject | fused nitrogenated heterocycles | es_ES |
dc.subject | [4 + 2]-cycloaddition | es_ES |
dc.title | The Intramolecular Povarov Tool in the Construction of Fused Nitrogen-Containing Heterocycles | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s41061-023-00428-7 | es_ES |
dc.identifier.doi | 10.1007/s41061-023-00428-7 | |
dc.departamentoes | Química orgánica I | es_ES |
dc.departamentoeu | Kimika organikoa I | es_ES |
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Except where otherwise noted, this item's license is described as © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.