Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species
dc.contributor.author | Ugalde Arbizu, Maider | |
dc.contributor.author | Aguilera-Correa, John Jairo | |
dc.contributor.author | San Sebastián Larzabal, Eider | |
dc.contributor.author | Páez, Paulina L. | |
dc.contributor.author | Nogales, Estela | |
dc.contributor.author | Esteban, Jaime | |
dc.contributor.author | Gómez-Ruiz, Santiago | |
dc.date.accessioned | 2023-08-07T11:02:49Z | |
dc.date.available | 2023-08-07T11:02:49Z | |
dc.date.issued | 2023-07-05 | |
dc.identifier.citation | Pharmaceuticals 16(7) : (2023) // Article ID 961 | es_ES |
dc.identifier.issn | 1424-8247 | |
dc.identifier.uri | http://hdl.handle.net/10810/62120 | |
dc.description.abstract | Antibiotic resistance is a global problem and bacterial biofilms contribute to its development. In this context, this study aimed to perform the synthesis and characterization of seven materials based on silica mesoporous nanoparticles functionalized with three types of fluoroquinolones, along with Cu2+ or Ag+ species to evaluate the antibacterial properties against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa, including clinical and multi-drug-resistant strains of S. aureus and P. aeruginosa. In addition, in order to obtain an effective material to promote wound healing, a well-known proliferative agent, phenytoin sodium, was adsorbed onto one of the silver-functionalized materials. Furthermore, biofilm studies and the generation of reactive oxygen species (ROS) were also carried out to determine the antibacterial potential of the synthesized materials. In this sense, the Cu2+ materials showed antibacterial activity against S. aureus and E. coli, potentially due to increased ROS generation (up to 3 times), whereas the Ag+ materials exhibited a broader spectrum of activity, even inhibiting clinical strains of MRSA and P. aeruginosa. In particular, the Ag+ material with phenytoin sodium showed the ability to reduce biofilm development by up to 55% and inhibit bacterial growth in a “wound-like medium” by up to 89.33%. | es_ES |
dc.description.sponsorship | We gratefully acknowledge funding from the research project RTI2018-094322-B-I00 financed by MCIN/AEI/10.13039/501100011033/ and “ERDF A way of making Europe”, the Research Thematic Network RED2022-134091-T financed by MCIN/AEI/10.13039/501100011033, the University of the Basque Country UPV/EHU (GIC18/143) and (GIU20/028) and the Gobierno Vasco/Eusko Jaurlaritza (IT1755-22). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RTI2018-094322-B-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/RED2022-134091-T | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | MSN | es_ES |
dc.subject | fluoroquinolone | es_ES |
dc.subject | copper | es_ES |
dc.subject | silver chloride | es_ES |
dc.subject | biofilm | es_ES |
dc.title | Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2023-07-28T12:21:48Z | |
dc.rights.holder | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1424-8247/16/7/961 | es_ES |
dc.identifier.doi | 10.3390/ph16070961 | |
dc.departamentoes | Química aplicada | |
dc.departamentoeu | Kimika aplikatua |
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Except where otherwise noted, this item's license is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).