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An Approach to the Synthesis of a Hepatitis C Virus Inhibitor through a Proline-Catalyzed 1,3-Dipolar Cycloaddition Using Acrolein

dc.contributor.authorUgarriza Serrano, Iratxe
dc.contributor.authorReyes Martín, Efraim
dc.contributor.authorPrieto Aretxabaleta, Liher ORCID
dc.contributor.authorUria Pujana, Uxue ORCID
dc.contributor.authorCarrillo Fernández, María Luisa ORCID
dc.contributor.authorVicario Hernando, José Luis ORCID
dc.date.accessioned2023-12-15T08:28:38Z
dc.date.available2023-12-15T08:28:38Z
dc.date.issued2021-09-06
dc.identifier.citationSynthesis 54(04) : 1101-1107(2022)es_ES
dc.identifier.issn0039-7881
dc.identifier.issn1437-210X
dc.identifier.urihttp://hdl.handle.net/10810/63394
dc.description.abstractAn efficient and easy protocol for performing 1,3-dipolar cycloaddition using azomethine ylides and acrolein is presented. The reaction catalyzed by d-proline allows the synthesis of C-3 unsubstituted pyrrolidines. The application of this methodology to the synthesis of an advanced intermediate in the preparation of a Hepatitis C virus inhibitor is presented. Final attempts to complete the synthesis of the target inhibitor results in the preparation of its C-4 epimer in good overall yieldes_ES
dc.description.sponsorshipSpanish MCIU (FEDER-CTQ2017-83633P y FEDERPID2020-118422-GB-100), Basque Government (Grupos IT908-16)es_ES
dc.language.isoenges_ES
dc.publisherThiemees_ES
dc.relationinfo:eu-repo/grantAgreement/MCIU/FEDER-CTQ2017-83633Pes_ES
dc.relationinfo:eu-repo/grantAgreement/MCIU/FEDERPID2020-118422-GB-100es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectprolinoles_ES
dc.subjectcycloadditiones_ES
dc.subjectdipolees_ES
dc.subjectpyrrolidinees_ES
dc.subjectaminomalonatees_ES
dc.subjectacroleines_ES
dc.subjectylideses_ES
dc.titleAn Approach to the Synthesis of a Hepatitis C Virus Inhibitor through a Proline-Catalyzed 1,3-Dipolar Cycloaddition Using Acroleines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2021. Thieme. All rights reservedes_ES
dc.relation.publisherversionhttps://doi.org/10.1055/s-0040-1719858es_ES
dc.identifier.doi10.1055/s-0040-1719858
dc.departamentoesQuímica Orgánica e Inorgánicaes_ES
dc.departamentoeuKimika Organikoa eta Ez-Organikoaes_ES


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