Intracellular transformation and disposal mechanisms of magnetosomes in macrophages and cancer cells
dc.contributor.author | Gandarias Albaina, Lucia ![]() | |
dc.contributor.author | Gascón Fernández Gubieda, Alicia | |
dc.contributor.author | Gorni, Giulio | |
dc.contributor.author | Mathon, Olivier | |
dc.contributor.author | Olivi, Luca | |
dc.contributor.author | Abad Díaz de Cerio, Ana ![]() | |
dc.contributor.author | Fernández Gubieda Ruiz, María Luisa | |
dc.contributor.author | Muela Blázquez, Alicia | |
dc.contributor.author | García Prieto, Ana | |
dc.date.accessioned | 2023-12-21T18:14:18Z | |
dc.date.available | 2023-12-21T18:14:18Z | |
dc.date.issued | 2023-10 | |
dc.identifier.citation | Biotechnology Journal 18(10) : (2023) // Article ID 2300173 | es_ES |
dc.identifier.issn | 1860-6768 | |
dc.identifier.issn | 1860-7314 | |
dc.identifier.uri | http://hdl.handle.net/10810/63490 | |
dc.description.abstract | Magnetosomes are magnetite nanoparticles biosynthesized by magnetotactic bacteria. They have been proposed for several biomedical applications mostly focused on the treatment and diagnosis of cancer. In this work we follow the intracellular long-term fate of magnetosomes in cancer cells and macrophages. We observe that cells dispose of magnetosomes using three main mechanisms: splitting into daughter cells in cell division, excretion to the surrounding environment and intracellular degradation. A deeper insight into the later mechanism by means of X-ray absorption spectroscopy reveals that in both cell types studied there is a first oxidation of magnetite to maghemite and a subsequent appearance of ferrihydrite, the iron mineral phase stored in the cores of ferritin proteins, suggesting that cells use the iron released from the degradation of magnetosomes to load ferritin. | es_ES |
dc.description.sponsorship | This work was supported by the grant PID2020-115704RB-C31 funded by MCIN/AEI/10.13039/501100011033 and by the grant IT1479-22 funded by the Basque Government. L.G. would like to thank the financial support from the grant PRE2018-083255 funded by MCIN/AEI/10.13039/501100011033 and by European Union NextGenerationEU/PRTR. G.G. acknowledges financial support from the grant FJC 2020-044866-I funded by MCIN/AEI/10.130339/501100011033 and European Union NextGeneration EU/PRTR. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-115704RB-C31 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/PRE2018-083255 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/FJC 2020-044866-I | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | biomedical applications | es_ES |
dc.subject | magnetic nanoparticle degradation | es_ES |
dc.subject | magnetosomes | es_ES |
dc.subject | magnetotactic bacteria | es_ES |
dc.subject | X-ray absorption spectroscopy | es_ES |
dc.title | Intracellular transformation and disposal mechanisms of magnetosomes in macrophages and cancer cells | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2023 The Authors.Biotechnology Journal published by Wiley-VCHGmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License,which permits use,distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1002/biot.202300173 | es_ES |
dc.identifier.doi | 10.1002/biot.202300173 | |
dc.departamentoes | Electricidad y electrónica | es_ES |
dc.departamentoes | Inmunología, microbiología y parasitología | es_ES |
dc.departamentoeu | Elektrizitatea eta elektronika | es_ES |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia | es_ES |
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Except where otherwise noted, this item's license is described as © 2023 The Authors.Biotechnology Journal published by Wiley-VCHGmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License,which permits use,distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.