dc.contributor.author | Ramos Díez, Sandra | |
dc.contributor.author | Larrañaga Jaurrieta, Garazi | |
dc.contributor.author | Iturriaga, Leire | |
dc.contributor.author | Abarrategi, Ander | |
dc.contributor.author | Camarero Espinosa, Sandra | |
dc.date.accessioned | 2023-12-22T14:49:41Z | |
dc.date.available | 2023-12-22T14:49:41Z | |
dc.date.issued | 2023-08 | |
dc.identifier.citation | Biomaterials Science 11(15) : 5163-5176 (2023) | es_ES |
dc.identifier.issn | 2047-4830 | |
dc.identifier.issn | 2047-4849 | |
dc.identifier.uri | http://hdl.handle.net/10810/63506 | |
dc.description.abstract | Digital light processing (DLP) printing offers the possibility of fabricating complex objects in a fast and reproducible manner. A main requirement for DLP printing is the use of inks with low viscosities that can flow under the printing platform in a short period of time. Its exploitation in tissue engineering applications has been centered on the use of hydrogel forming materials diluted in aqueous solutions or the use of polyesters in combination with diluents and heating platforms that aid in the reduction of their viscosity. The use of diluents, however, modifies the mechanical properties and reduces the shape fidelity of the printed objects and, the use of heating platforms results in vats with heterogeneous temperatures and ink viscosities. Here, we report on the synthesis of a library of methacrylated low molecular weight (<3000 g mol−1) homopolymers ((P(D,L)LA and PCL) and copolymers (P((D,L)LA-co-CL)) of 2- and 3-arms based on (D,L)-lactide and ε-caprolactone. The resulting inks possessed low viscosity that made them printable in the absence of diluents and heating elements. DLP printing of cubical and cylindrical patterns resulted in objects with a higher shape fidelity than their counterparts fabricated using diluents and with printed features on the order of 300 μm. The printed materials were biocompatible and supported the growth of human mesenchymal stem cells (hMSCs). Moreover, the variations in the composition resulted in polymers that enabled the attachment of hMSCs to different extents, leading to the formation of well-adhered cell monolayers or loosely adhered cell aggregates. | es_ES |
dc.description.sponsorship | The authors acknowledge the funding bodies and support through the EMAKIKER grant. S. C.-E. acknowledges the Spanish Ministry of Science and Innovation (MICINN) – State Investigation Agency (AEI) (PID2020-114901RA-I00). S. C.-E. and S. R.-D. acknowledge the Basque Government (PIBA_2022_1_0006). G. L.-J. acknowledges the Basque Government Predoctoral grant PRE_2021_1_0403. S. C.-E. and L. I. acknowledge the Provincial Council of Guipuzcoa. The project that gave rise to these results received the support of a fellowship from the “laCaixa” Foundation (ID100010434). The fellowship code is 117145. S. C.-E. acknowledges funding from the University of the Basque Country UPV/EHU within the framework of Grupos de Investigación (GIU21/033). A. A. acknowledges funding from PID2021-127191OB-I00 and RTI2018-101708-A-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”. Grant RYC2018-025502-I funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future”. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | RSC | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-114901RA-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2021-127191OB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RTI2018-101708-A-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RYC2018-025502-I | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.title | Low molecular weight poly((d,l)-lactide-co-caprolactone) liquid inks for diluent-free DLP printing of cell culture platforms | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Royal Society of Chemistry 2023 . This article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlelanding/2023/bm/d3bm00581j | es_ES |
dc.identifier.doi | 10.1039/d3bm00581j | |