dc.contributor.author | Llorens Villar, Yanire | |
dc.contributor.author | Tusell Palmer, Fernando Jorge ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Canut Blasco, Andrés | |
dc.contributor.author | Barrasa González, Helena | |
dc.contributor.author | Corral, Esther | |
dc.contributor.author | Martín, Alejandro | |
dc.contributor.author | Rodríguez Gascón, Alicia | |
dc.date.accessioned | 2024-01-12T19:26:25Z | |
dc.date.available | 2024-01-12T19:26:25Z | |
dc.date.issued | 2019-05-07 | |
dc.identifier.citation | Journal of Antimicrobial Chemotherapy 74(8) : 2289-2294 (2019) | es_ES |
dc.identifier.issn | 1460-2091 | |
dc.identifier.uri | http://hdl.handle.net/10810/63949 | |
dc.description.abstract | Objectives: The aim of this study was to compare antimicrobial susceptibility rates in a Spanish ICU before and after the introduction of selective digestive decontamination (SDD) and also to compare these with susceptibility data from other Spanish ICUs without SDD.
Methods: We performed a retrospective study in the ICU of the University Hospital of Alava, where SDD was implemented in 2002. The SDD protocol consisted of a 2% mixture of gentamicin, colistin and amphotericin B applied on the buccal mucosa and a suspension of the same drugs in the gastrointestinal tract; additionally, for the first 3 days, systemic ceftriaxone was administered. From 1998 to 2013 we analysed the susceptibility rates for 48 antimicrobial/organism combinations. Interrupted time series using a linear dynamic model with SDD as an intervention was used. Data from other ICUs were obtained fromthe ENVIN-HELICS national registry.
Results: Only amoxicillin/clavulanic acid against Escherichia coli and Proteus mirabilis, and a high concentration of gentamicin against Enterococcus faecalis, resulted in a significant decrease in the susceptibility rate after the implementation of SDD, with a drop of 20%, 27% and 32%, respectively. Compared with other Spanish ICUs without SDD, the susceptibility ratewas higher in the ICU of our hospital inmost cases.When itwas lower, differences were <10%, except for a high concentration of streptomycin against Enterococcus faecium, for which the difference was 19%.
Conclusions: No relevant changes in the overall susceptibility rate after the implementation of SDD were
detected. Susceptibility rates were not lower than those in the Spanish ICUs without SDD. | es_ES |
dc.description.sponsorship | This work was supported by the University of the Basque Country UPV/EHU (GIU17/32, PPG17/65). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.title | Antibiotic susceptibility trend before and after long-term use of selective digestive decontamination: a 16 year ecological study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | (c) The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com. | es_ES |
dc.relation.publisherversion | https://academic.oup.com/jac/article/74/8/2289/5486502 | es_ES |
dc.identifier.doi | 10.1093/jac/dkz186 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | es_ES |
dc.departamentoeu | Farmazia eta elikagaien zientziak | es_ES |