Omega-3 Recovers Cannabinoid 1 Receptor Expression in the Adult Mouse Brain after Adolescent Binge Drinking
dc.contributor.author | Martín Llorente, Ane | |
dc.contributor.author | Serrano Murgia, Maitane ![]() | |
dc.contributor.author | Bonilla del Río, Itziar | |
dc.contributor.author | Lekunberri, Leire | |
dc.contributor.author | Ocerin Amondarain, Garazi | |
dc.contributor.author | Puente Bustinza, Nagore ![]() | |
dc.contributor.author | Ramos Uriarte, Almudena ![]() | |
dc.contributor.author | Rico Barrio, Irantzu | |
dc.contributor.author | Gerrikagoitia Marina, Inmaculada ![]() | |
dc.contributor.author | Grandes Moreno, Pedro Rolando ![]() | |
dc.date.accessioned | 2024-02-02T16:26:40Z | |
dc.date.available | 2024-02-02T16:26:40Z | |
dc.date.issued | 2023-12-10 | |
dc.identifier.citation | International Journal of Molecular Sciences 24(24) : (2023) // Article ID 17316 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10810/64597 | |
dc.description.abstract | Adolescent binge drinking is a social problem with a long-lasting impact on cognitive functions. The cannabinoid type-1 (CB1) receptor of the endocannabinoid system (ECS) is involved in brain synaptic plasticity, cognition and behavior via receptor localization at specific subcellular compartments of the cortical, limbic and motor regions. Alcohol (EtOH) intake affects the ECS, CB1 and their functions. Evidence indicates that binge drinking during adolescence impairs memory via the abrogation of CB1-dependent synaptic plasticity in the hippocampus. However, the impact of EtOH consumption on global CB1 receptor expression in the adult brain is unknown. We studied this using optical density analysis throughout brain regions processed for light microscopy (LM) immunohistotochemistry. CB1 staining decreased significantly in the secondary motor cortex, cerebellum, cingulate cortex, amygdala and nucleus accumbens. Next, as omega-3 (n-3) polyunsaturated fatty acids (PUFAs) rescue synaptic plasticity and improve EtOH-impaired cognition, we investigated whether docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) had any effect on CB1 receptors. N-3 intake during EtOH abstinence restored CB1 immunostaining in the secondary motor cortex, cerebellum and amygdala, and ameliorated receptor density in the cingulate cortex. These results show that n-3 supplementation recovers CB1 receptor expression disrupted by EtOH in distinct brain regions involved in motor functions and cognition. | es_ES |
dc.description.sponsorship | This work has been supported by The Basque Government (IT1620-22); Red de Investigación en Atención Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III (RD21/0009/0006); Red de Trastornos Adictivos, Instituto de Salud Carlos III, European Regional Development Funds-European Union (ERDF-EU; RD16/0017/0012); and Ministry of Science and Innovation (PID2019-107548RB-I00). M.S. is in receipt of a PhD contract from The University of the Basque Country (PIF 19/164). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-107548RB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/es/ | |
dc.subject | ethanol | es_ES |
dc.subject | polyunsaturated fatty acids | es_ES |
dc.subject | endocannabinoid system | es_ES |
dc.subject | immunohistochemistry | es_ES |
dc.subject | motor system | es_ES |
dc.subject | cognition | es_ES |
dc.subject | rodent | es_ES |
dc.title | Omega-3 Recovers Cannabinoid 1 Receptor Expression in the Adult Mouse Brain after Adolescent Binge Drinking | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2023-12-22T13:45:51Z | |
dc.rights.holder | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/24/24/17316 | es_ES |
dc.identifier.doi | 10.3390/ijms242417316 | |
dc.departamentoes | Neurociencias | |
dc.departamentoeu | Neurozientziak |
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Except where otherwise noted, this item's license is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).