Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing
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Date
2019-07Author
Frosch, Timea
Aldabaldetreku Etxeberria, Gotzon
Zubia Zaballa, Joseba Andoni
Popp, Jurgen
Frosch, Torsten
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Journal of Lightwave Technology 37(13) : 2981-2988 (2019)
Abstract
[EN] This work reports the development and application
of two liquid-core microstructured polymer optical fibers (LCmPOF)
with different microstructure sizes. They are used in a
fiber-enhanced Raman spectroscopy sensing platform,with the aim
of detecting glucose in aqueous solutions in the clinically relevant
range for sodium–glucose cotransporter 2 inhibitor therapy. The
sensing platform is tested for low-concentration glucose solutions
using each LC-mPOF. Results confirm that a significant enhancement
of theRaman signal is achieved in comparison to conventional
Raman spectroscopy. Additional measurements are carried out to
obtain the valid measurement range, the resolution, and the limit of
detection, showing that the LC-mPOF with 66-μm-diameter central
hollow core has the highest potential for future clinical applications.
Finally, preliminary tests successfully demonstrate glucose
identification in urine.