dc.contributor.author | Soler Blasco, Raquel | |
dc.contributor.author | Harari, Florencia | |
dc.contributor.author | Riutort Mayol, Gabriel | |
dc.contributor.author | Murcia, Mario | |
dc.contributor.author | Lozano, Manuel | |
dc.contributor.author | Irizar Loibide, Amaia | |
dc.contributor.author | Santa Marina Rodríguez, Loreto | |
dc.contributor.author | Zubero Oleagoitia, Miren Begoña | |
dc.contributor.author | Fernández Jiménez, Nora | |
dc.contributor.author | Braeuer, Simone | |
dc.contributor.author | Ballester, Ferrán | |
dc.contributor.author | Llop, Sabrina | |
dc.date.accessioned | 2024-02-08T09:44:24Z | |
dc.date.available | 2024-02-08T09:44:24Z | |
dc.date.issued | 2023-07-24 | |
dc.identifier.citation | Science of the Total Environment 900 : (2023) // Article ID 165740 | es_ES |
dc.identifier.issn | 0048-9697 | |
dc.identifier.issn | 1879-1026 | |
dc.identifier.uri | http://hdl.handle.net/10810/65117 | |
dc.description.abstract | Inorganic arsenic (iAs) is a widespread toxic metalloid. It is well-known that iAs metabolism and its toxicity are mediated by polymorphisms in AS3MT and other genes. However, studies during pregnancy are scarce. We aimed to examine the role of genetic polymorphisms in AS3MT, GSTO2, N6AMT1, MTHFR, MTR, FTCD, CBS, and FOLH1 in iAs methylation efficiency during pregnancy. The study included 541 pregnant participants from the INMA (Environment and Childhood) Spanish cohort. Using high-performance liquid chromatography coupled to inductively coupled plasma-tandem mass, we measured arsenic (iAs and the metabolites monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA)) in urine samples collected during the first trimester. iAs methylation efficiency was determined based on relative concentrations of the As metabolites in urine (%MMA, %DMA, and %iAs). Thirty-two single nucleotide polymorphisms (SNPs) in nine genes were determined in maternal DNA; AS3MT haplotypes were inferred. We assessed the association between genotypes/haplotypes and maternal As methylation efficiency using multivariate linear regression models. The median %MMA and %DMA were 5.3 %, and 89 %, respectively. Ancestral alleles of AS3MT SNPs (rs3740393, rs3740390, rs11191453, and rs11191454) were significantly associated with higher %MMA, %iAs, and lower %DMA. Pregnant participants with zero copies of the GGCTTCAC AS3MT haplotype presented a higher %MMA. Statistically significant associations were also found for the FOLH1 SNP rs202676 (β 0.89 95%CI: 0.24, 1.55 for carriers of the G allele vs. the A allele). Our study shows that ancestral alleles in AS3MT polymorphisms were associated with lower As methylation efficiency in early pregnancy and suggests that FOLH1 also plays a role in As methylation efficiency. These results support the hypothesis that As metabolism is multigenic, being a key element for identifying susceptible populations. | es_ES |
dc.description.sponsorship | This work has been funded by the Instituto de Salud Carlos III, Spain,
through the projects PI06/0867, FIS-FEDER: 13/1944, 16/1288, PI18/
01142, 19/1338; PI09/00090, Miguel Servet-FEDER: CP15/0025,
CPII20/00006; CD21/00186; FIS-FSE: 17/00260; Miguel Servet-FSE:
MS15/0025, MS20/0006 and co-funded by the European Union and
H2020-EU No 874583 (ATHLETE project). Also, this study was sup-
ported by grants from the Generalitat Valenciana, Spain (CIAICO/2021/
132, BEST/2020/059 and AICO 2020/285), Department of Health of the
Basque Government [2005111093 and GVSAN2018111086], Provincial
Government of Gipuzkoa [DFG06/002], annual agreements with the
municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia
and Azpeitia and Beasain), Gobierno de Espa˜na through the Spanish
Ministry of Universities (Margarita Salas Grant MS21-133, grant CAS21/
00008 and a grant for the requalification of the Spanish university) and
co-funded by the European Union- Next Generation EU, Sahlgrenska
University Hospital and IRIS stipendium. | |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/EU/H2020/874583 | |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | arsenic | |
dc.subject | single nucleotide polymorphisms | |
dc.subject | haplotypes | |
dc.subject | pregnancy | |
dc.subject | prenatal exposure | |
dc.subject | arsenic metabolism | |
dc.title | Influence of genetic polymorphisms on arsenic methylation efficiency during pregnancy: Evidence from a Spanish birth cohort | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license | |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0048969723043632 | |
dc.identifier.doi | /10.1016/j.scitotenv.2023.165740 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |