dc.contributor.author | García-Forn, Marta | |
dc.contributor.author | Martínez-Torres, Sara | |
dc.contributor.author | García-Díaz Barriga, Gerardo | |
dc.contributor.author | Alberch, Jordi | |
dc.contributor.author | Milà, Montse | |
dc.contributor.author | Azkona Mendoza, Garikoitz ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Pérez Navarro, Esther | |
dc.date.available | 2024-02-08T09:58:39Z | |
dc.date.issued | 2018-08-31 | |
dc.identifier.citation | Neurobiology of Disease 120 : 88-97 (2018) | es_ES |
dc.identifier.issn | 1095-953X | |
dc.identifier.issn | 0969-9961 | |
dc.identifier.uri | http://hdl.handle.net/10810/65185 | |
dc.description.abstract | Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expansion of a CAG repeat in the huntingtin (htt) gene, which results in an aberrant form of the protein (mhtt). This leads to motor and cognitive deficits associated with corticostriatal and hippocampal alterations. The levels of STriatal-Enriched protein tyrosine Phosphatase (STEP), a neural-specific tyrosine phosphatase that opposes the development of synaptic strengthening, are decreased in the striatum of HD patients and also in R6/1 mice, thereby contributing to the resistance to excitotoxicity described in this HD mouse model. Here, we aimed to analyze whether STEP inactivation plays a role in the pathophysiology of HD by investigating its effect on motor and cognitive impairment in the R6/1 mouse model of HD. We found that genetic deletion of STEP delayed the onset of motor dysfunction and prevented the appearance of cognitive deficits in R6/1 mice. This phenotype was accompanied by an increase in pERK1/2 levels, a delay in the decrease of striatal DARPP-32 levels and a reduction in the size of mhtt aggregates, both in the striatum and CA1 hippocampal region. We also found that acute pharmacological inhibition of STEP with TC-2153 improved cognitive function in R6/1 mice. In conclusion, our results show that deletion of STEP has a beneficial effect on motor coordination and cognition in a mouse model of HD suggesting that STEP inhibition could be a good therapeutic strategy in HD patients. | es_ES |
dc.description.sponsorship | This work was supported by the project PI13/01250 integrado en el
Plan Nacional de I+D+I y cofinanciado por el ISCIII-Subdirección General
de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER), and
grants SAF2016-08573-R (to E.P.-N.) and SAF2017-88076-R (to J.A,)
from Ministerio de Economia y Competitividad, Spain. | |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | cognitive function | es_ES |
dc.subject | DARPP-32 | |
dc.subject | Hippocampus | |
dc.subject | motor coordination | |
dc.subject | mutant huntingtin aggregates | |
dc.subject | striatum | |
dc.subject | phosphoERK1/2 | |
dc.title | Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2018 Elsevier under CC BY-NC-ND license | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0969996118305175 | |
dc.identifier.doi | 10.1016/j.nbd.2018.08.024 | |
dc.departamentoes | Procesos psicológicos básicos y su desarrollo | es_ES |
dc.departamentoeu | Oinarrizko psikologia prozesuak eta haien garapena | es_ES |