dc.contributor.author | Pellón Rodríguez, Aize | |
dc.contributor.author | Ramírez García, Andoni | |
dc.contributor.author | Guruceaga Sierra, Xabier | |
dc.contributor.author | Zabala Olaizola, Alazne | |
dc.contributor.author | Buldain Garriz, Idoia | |
dc.contributor.author | Antorán Díaz, Aitziber | |
dc.contributor.author | Anguita Castillo, Juan de Dios | |
dc.contributor.author | Rementeria Ruiz, Aitor Domingo | |
dc.contributor.author | Matute Almau, Carlos José | |
dc.contributor.author | Hernando Echevarria, Fernando Luis | |
dc.date.accessioned | 2024-02-08T11:44:13Z | |
dc.date.available | 2024-02-08T11:44:13Z | |
dc.date.issued | 2018-03-26 | |
dc.identifier.citation | Cellular Microbiology 20(8) : (2018) // Article ID 12847 | es_ES |
dc.identifier.issn | 1462-5814 | |
dc.identifier.uri | http://hdl.handle.net/10810/65716 | |
dc.description.abstract | Lomentospora (Scedosporium) prolificans is an opportunistic pathogen capable of causing invasive infections in immunocompromised patients. The fungus is able to disseminate via the bloodstream finally arriving at the central nervous system producing neurological symptoms and, in many cases, patient death. In this context, microglial cells, which are the resident immune cells in the central nervous system, may play an important role in these infections. However, this aspect of anti-L. prolificans immunity has been poorly researched to date. Thus, the interactions and activity of microglial cells against L. prolificans were analysed, and the results show that there was a remarkable impairment in their performance regarding phagocytosis, the development of oxidative burst, and in the production of pro-inflammatory cytokines, compared with macrophages. Interestingly, L. prolificans displays great growth also when challenged with immune cells, even when inside them. We also proved that microglial phagocytosis of the fungus is highly dependent on mannose receptor and especially on dectin-1. Taken together, these data provide evidence for an impaired microglial response against L. prolificans and contribute to understanding the pathobiology of its neurotropism. | es_ES |
dc.description.sponsorship | This work has been supported by grants (GIU15/36, UFI11/25, and PPG17/41) from the UPV/EHU and SAF2016‐75292‐R from the Spanish Ministry of Economy, Industry and Competitiveness (MINECO). I. B. and A. A. are recipients of predoctoral grants from the Basque Government (GV/EJ). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2016-75292-R | |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | CNS infections | es_ES |
dc.subject | antifungal immunity | es_ES |
dc.subject | filamentous fungi | es_ES |
dc.subject | microglia | es_ES |
dc.title | Microglial immune response is impaired against the neurotropic fungus Lomentospora prolificans | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2018 John Wiley & Sons Ltd | es_ES |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/epdf/10.1111/cmi.12847 | es_ES |
dc.identifier.doi | /10.1111/cmi.12847 | |
dc.departamentoes | Inmunología, microbiología y parasitología | es_ES |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |