Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications
dc.contributor.author | Guruceaga Sierra, Xabier | |
dc.contributor.author | Pérez Cuesta, Uxue | |
dc.contributor.author | Abad Díaz de Cerio, Ana ![]() | |
dc.contributor.author | González Mendia, Oscar ![]() | |
dc.contributor.author | Alonso Rojas, Rosa María ![]() | |
dc.contributor.author | Hernando, Fernando Luis | |
dc.contributor.author | Ramírez García, Andoni | |
dc.contributor.author | Rementeria Ruiz, Aitor Domingo | |
dc.date.accessioned | 2024-02-08T12:31:17Z | |
dc.date.available | 2024-02-08T12:31:17Z | |
dc.date.issued | 2019-12-20 | |
dc.identifier.citation | Toxins 12(1) : 2020 // Article ID 7 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10810/65758 | |
dc.description.abstract | Fumagillin is a mycotoxin produced, above all, by the saprophytic filamentous fungus Aspergillus fumigatus. This mold is an opportunistic pathogen that can cause invasive aspergillosis, a disease that has high mortality rates linked to it. Its ability to adapt to environmental stresses through the production of secondary metabolites, including several mycotoxins (gliotoxin, fumagillin, pseurotin A, etc.) also seem to play an important role in causing these infections. Since the discovery of the A. fumigatus fumagillin in 1949, many studies have focused on this toxin and in this review we gather all the information currently available. First of all, the structural characteristics of this mycotoxin and the different methods developed for its determination are given in detail. Then, the biosynthetic gene cluster and the metabolic pathway involved in its production and regulation are explained. The activity of fumagillin on its target, the methionine aminopeptidase type 2 (MetAP2) enzyme, and the effects of blocking this enzyme in the host are also described. Finally, the applications that this toxin and its derivatives have in different fields, such as the treatment of cancer and its microsporicidal activity in the treatment of honeybee hive infections with Nosema spp., are reviewed. Therefore, this work offers a complete review of all the information currently related to the fumagillin mycotoxin secreted by A. fumigatus, important because of its role in the fungal infection process but also because it has many other applications, notably in beekeeping, the treatment of infectious diseases, and in oncology. | es_ES |
dc.description.sponsorship | This research was funded by the Basque Government, grant number IT1362-19. X.G. and U.P.-C. were funded by the Basque Government and the UPV/EHU, respectively. | |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | fumagillin | es_ES |
dc.subject | Aspergillus fumigatus | es_ES |
dc.subject | chemical detection | es_ES |
dc.subject | metabolic pathway and regulation | es_ES |
dc.subject | MetAP2 enzyme | es_ES |
dc.subject | cancer treatment | es_ES |
dc.subject | mirosporicidal activity | es_ES |
dc.subject | honeybee hive infections | es_ES |
dc.title | Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | * |
dc.relation.publisherversion | https://www.mdpi.com/2072-6651/12/1/7 | |
dc.identifier.doi | 10.3390/toxins12010007 |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).