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dc.contributor.authorGandarias Albaina, Lucia ORCID
dc.contributor.authorJefremovas, Elizabeth M.
dc.contributor.authorGandia Aguado, David
dc.contributor.authorMarcano Prieto, Lourdes
dc.contributor.authorMartínez Martínez, Virginia ORCID
dc.contributor.authorRamos Cabrer, Pedro
dc.contributor.authorChevrier, Daniel M.
dc.contributor.authorValencia, Sergio
dc.contributor.authorFernández Barquín, Luis
dc.contributor.authorFernández Gubieda Ruiz, María Luisa
dc.contributor.authorAlonso, Javier
dc.contributor.authorGarcía Prieto, Ana
dc.contributor.authorMuela Blázquez, Alicia
dc.date.accessioned2024-02-09T16:08:06Z
dc.date.available2024-02-09T16:08:06Z
dc.date.issued2023-05-24
dc.identifier.citationMaterials Today Bio 20 : (2023) // Article ID 100680es_ES
dc.identifier.issn2590-0064
dc.identifier.urihttp://hdl.handle.net/10810/65967
dc.description.abstractMagnetotactic bacteria are envisaged as potential theranostic agents. Their internal magnetic compass, chemical environment specificity and natural motility enable these microorganisms to behave as nanorobots, as they can be tracked and guided towards specific regions in the body and activated to generate a therapeutic response. Here we provide additional diagnostic functionalities to magnetotactic bacteria Magnetospirillum gryphiswaldense MSR-1 while retaining their intrinsic capabilities. These additional functionalities are achieved by incorporating Tb or Gd in the bacteria by culturing them in Tb/Gd supplemented media. The incorporation of Tb provides luminescence properties, enabling potential applications of bacteria as biomarkers. The incorporation of Gd turns bacteria into dual contrast agents for magnetic resonance imaging, since Gd adds T1 contrast to the existing T2 contrast of unmodified bacteria. Given their potential clinical applications, the diagnostic ability of the modified MSR-1 has been successfully tested in vitro in two cell models, confirming their suitability as fluorescent markers (Tb-MSR-1) and dual contrast agents for MRI (Gd-MSR-1).es_ES
dc.description.sponsorshipThis work has been funded by the Spanish Government (grants PID2020-115704RB-C31, PID2020-114347RB-C32, PID2020-115704RB-C33 and RED 2018–102626–T (HIPERNANO) funded by MCIN/AEI/10.13039/501100011033) and by the Basque Government (projects IT1479-22 and IT1639-22). LG acknowledges the Spanish Government for her PhD/Postdoctoral fellowship (PRE2018-083255 funded by MCIN/AEI/10.13039/501100011033 and by European Union Next GenerationEU/PRTR). EMJ acknowledges the Beca Concepción Arenal (Gobierno de Cantabria – Grant n. 406333) and Alexander von Humboldt Postdoctoral Fellowship. LM acknowledges the BBVA Foundation for the Leonardo Fellowships for Researchers and Cultural Creators 2022.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationinfo:eu-repo/grantAgreement/MICIN/RED 2018-102626-T
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectmagnetotactic bacteriaes_ES
dc.subjecttheranostic agentses_ES
dc.subjectluminescent markerses_ES
dc.subjectmagnetic resonance imaginges_ES
dc.subjectX-ray absorption spectroscopyes_ES
dc.subjectmagnetic hyperthermiaes_ES
dc.titleIncorporation of Tb and Gd improves the diagnostic functionality of magnetotactic bacteriaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2023 The Authors. Published by Elsevier Ltd. This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.es_ES
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2590006423001400es_ES
dc.identifier.doi10.1016/j.mtbio.2023.100680
dc.departamentoesFísica Aplicada
dc.departamentoeuFisika Aplikatua


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© 2023 The Authors. Published by Elsevier Ltd. 
This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.
Except where otherwise noted, this item's license is described as © 2023 The Authors. Published by Elsevier Ltd. This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.