Incorporation of Tb and Gd improves the diagnostic functionality of magnetotactic bacteria
dc.contributor.author | Gandarias Albaina, Lucia | |
dc.contributor.author | Jefremovas, Elizabeth M. | |
dc.contributor.author | Gandia Aguado, David | |
dc.contributor.author | Marcano Prieto, Lourdes | |
dc.contributor.author | Martínez Martínez, Virginia | |
dc.contributor.author | Ramos Cabrer, Pedro | |
dc.contributor.author | Chevrier, Daniel M. | |
dc.contributor.author | Valencia, Sergio | |
dc.contributor.author | Fernández Barquín, Luis | |
dc.contributor.author | Fernández Gubieda Ruiz, María Luisa | |
dc.contributor.author | Alonso, Javier | |
dc.contributor.author | García Prieto, Ana | |
dc.contributor.author | Muela Blázquez, Alicia | |
dc.date.accessioned | 2024-02-09T16:08:06Z | |
dc.date.available | 2024-02-09T16:08:06Z | |
dc.date.issued | 2023-05-24 | |
dc.identifier.citation | Materials Today Bio 20 : (2023) // Article ID 100680 | es_ES |
dc.identifier.issn | 2590-0064 | |
dc.identifier.uri | http://hdl.handle.net/10810/65967 | |
dc.description.abstract | Magnetotactic bacteria are envisaged as potential theranostic agents. Their internal magnetic compass, chemical environment specificity and natural motility enable these microorganisms to behave as nanorobots, as they can be tracked and guided towards specific regions in the body and activated to generate a therapeutic response. Here we provide additional diagnostic functionalities to magnetotactic bacteria Magnetospirillum gryphiswaldense MSR-1 while retaining their intrinsic capabilities. These additional functionalities are achieved by incorporating Tb or Gd in the bacteria by culturing them in Tb/Gd supplemented media. The incorporation of Tb provides luminescence properties, enabling potential applications of bacteria as biomarkers. The incorporation of Gd turns bacteria into dual contrast agents for magnetic resonance imaging, since Gd adds T1 contrast to the existing T2 contrast of unmodified bacteria. Given their potential clinical applications, the diagnostic ability of the modified MSR-1 has been successfully tested in vitro in two cell models, confirming their suitability as fluorescent markers (Tb-MSR-1) and dual contrast agents for MRI (Gd-MSR-1). | es_ES |
dc.description.sponsorship | This work has been funded by the Spanish Government (grants PID2020-115704RB-C31, PID2020-114347RB-C32, PID2020-115704RB-C33 and RED 2018–102626–T (HIPERNANO) funded by MCIN/AEI/10.13039/501100011033) and by the Basque Government (projects IT1479-22 and IT1639-22). LG acknowledges the Spanish Government for her PhD/Postdoctoral fellowship (PRE2018-083255 funded by MCIN/AEI/10.13039/501100011033 and by European Union Next GenerationEU/PRTR). EMJ acknowledges the Beca Concepción Arenal (Gobierno de Cantabria – Grant n. 406333) and Alexander von Humboldt Postdoctoral Fellowship. LM acknowledges the BBVA Foundation for the Leonardo Fellowships for Researchers and Cultural Creators 2022. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIN/RED 2018-102626-T | |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | magnetotactic bacteria | es_ES |
dc.subject | theranostic agents | es_ES |
dc.subject | luminescent markers | es_ES |
dc.subject | magnetic resonance imaging | es_ES |
dc.subject | X-ray absorption spectroscopy | es_ES |
dc.subject | magnetic hyperthermia | es_ES |
dc.title | Incorporation of Tb and Gd improves the diagnostic functionality of magnetotactic bacteria | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2023 The Authors. Published by Elsevier Ltd. This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed. | es_ES |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2590006423001400 | es_ES |
dc.identifier.doi | 10.1016/j.mtbio.2023.100680 | |
dc.departamentoes | Física Aplicada | |
dc.departamentoeu | Fisika Aplikatua |
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This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.