Morphology and Mechanical Properties of PLLA and PCL Scaffolds
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2014-01-28Autor
Díaz Tajada, Esperanza
Sandonis Oleaga, Iván
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Polymer-Plastics Technology and Engineering 53(2) : 150-155 (2014)
Resumen
Human tissue engineering, comprising methods and tools to
create implants, is a promising although as yet a very underdeveloped
field of research into the regeneration of specific damaged or
necrotic tissue. Porous scaffolds play an important role in tissue
engineering. The porous cell culture scaffolds in this study were
produced through thermally induced phase separation (lyophilization).
This technique yields considerable variations in scaffold
microstructures (pore size and morphology) as a function of the
polymer, solvent and thermal processing. PLLA and PCL were used
with chloroform, 1,4-dioxane and water as solvent. We observed
a decrease in mechanical properties with increasing pore size in
the two polymers under study. However, we found that PLLA,
which possesses larger pore sizes than PCL, showed superior
mechanical properties, which we explain in terms of crystallinity.