Toxicogenomics of the Freshwater Oligochaete, Tubifex tubifex (Annelida, Clitellata), in Acute Water-Only Exposure to Arsenic
dc.contributor.author | Moreno Ocio, Iñigo | |
dc.contributor.author | Aquilino, Mónica | |
dc.contributor.author | Llorente, Lola | |
dc.contributor.author | Martínez Madrid, Maite | |
dc.contributor.author | Rodríguez, Pilar | |
dc.contributor.author | Méndez Fernández, Leire | |
dc.contributor.author | Planelló, Rosario | |
dc.date.accessioned | 2024-04-08T15:36:31Z | |
dc.date.available | 2024-04-08T15:36:31Z | |
dc.date.issued | 2024-03-16 | |
dc.identifier.citation | International Journal of Molecular Sciences 25(6) : (2024) // Article ID 3382 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10810/66544 | |
dc.description.abstract | A toxicogenomic approach was used for toxicity evaluation of arsenic in the aquatic environment, and differential gene expression was investigated from 24 h and 96 h water-only acute toxicity tests with the aquatic oligochaete, Tubifex tubifex (Annelida, Clitellata). Several toxicological endpoints (survival and autotomy) of the oligochaete and tissue residues were measured, and dose-response modelling of gene expression data was studied. A reference transcriptome of the aquatic oligochaete, T. tubifex, was reconstructed for the first time, and genes related to cell stress response (Hsc70, Hsp10, Hsp60, and Hsp83), energy metabolism (COX1), oxidative stress (Cat, GSR, and MnSOD), and the genes involved in the homeostasis of organisms (CaM, RpS13, and UBE2) were identified and characterised. The potential use of the genes identified for risk assessment in freshwater ecosystems as early biomarkers of arsenic toxicity is discussed. | es_ES |
dc.description.sponsorship | This research was funded by CGL 2013-44655-R/BOS research project sponsored by the Spanish Ministry of Economy, Industry and Competitiveness and the UNED projects 2018I/PPRO/008. The UPV/EHU university supported the pre-doctoral internship of Íñigo Moreno at UNED. Iñigo Moreno-Ocio was financed by a Ph.D. scholarship from the University of the Basque Country (UPV/EHU) from 2017–2021 (PIF16/162). Lola Llorente was co-financed by the Community of Madrid Government and the European Social Fund with a research assistant contract (PEJ-2017-AI/BIO-6834). Mónica Aquilino was co-financed by the Community of Madrid Government and the European Social Fund with a postdoctoral contract (PEJD-2019-POST/AMB-16425). She is financed by the Spanish Ministry of Universities and the European Union-NextGenerationUE with a María Zambrano grant to attract international talent. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | i | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/es/ | |
dc.subject | arsenic | es_ES |
dc.subject | oligochaeta | es_ES |
dc.subject | toxicity assay | es_ES |
dc.subject | transcriptional biomarker | es_ES |
dc.subject | cell stress response | es_ES |
dc.subject | oxidative stress | es_ES |
dc.subject | homeostasis | es_ES |
dc.subject | effect concentration | es_ES |
dc.subject | reference transcriptome | es_ES |
dc.title | Toxicogenomics of the Freshwater Oligochaete, Tubifex tubifex (Annelida, Clitellata), in Acute Water-Only Exposure to Arsenic | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2024-03-27T13:16:22Z | |
dc.rights.holder | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/25/6/3382 | es_ES |
dc.identifier.doi | 10.3390/ijms25063382 | |
dc.departamentoes | Zoología y biología celular animal | |
dc.departamentoes | Genética, antropología física y fisiología animal | |
dc.departamentoeu | Zoologia eta animalia zelulen biologia | |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia |
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Except where otherwise noted, this item's license is described as © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).