URB447 Is Neuroprotective in Both Male and Female Rats after Neonatal Hypoxia–Ischemia and Enhances Neurogenesis in Females
dc.contributor.author | Beldarrain González, Gorane | |
dc.contributor.author | Chillida Fibla, Marc | |
dc.contributor.author | Hilario Rodríguez, Enrique | |
dc.contributor.author | Herrero de la Parte, Borja | |
dc.contributor.author | Álvarez Díaz, Antonia Ángeles | |
dc.contributor.author | Alonso-Alconada, Daniel | |
dc.date.accessioned | 2024-04-10T12:31:04Z | |
dc.date.available | 2024-04-10T12:31:04Z | |
dc.date.issued | 2024-01-28 | |
dc.identifier.citation | International Journal of Molecular Sciences 25(3) : (2024) // Article ID 1607 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10810/66589 | |
dc.description.abstract | The need for new and effective treatments for neonates suffering from hypoxia–ischemia is urgent, as the only implemented therapy in clinics is therapeutic hypothermia, only effective in 50% of cases. Cannabinoids may modulate neuronal development and brain plasticity, but further investigation is needed to better describe their implication as a neurorestorative therapy after neonatal HI. The cannabinoid URB447, a CB1 antagonist/CB2 agonist, has previously been shown to reduce brain injury after HI, but it is not clear whether sex may affect its neuroprotective and/or neurorestorative effect. Here, URB447 strongly reduced brain infarct, improved neuropathological score, and augmented proliferative capacity and neurogenic response in the damaged hemisphere. When analyzing these effects by sex, URB447 ameliorated brain damage in both males and females, and enhanced cell proliferation and the number of neuroblasts only in females, thus suggesting a neuroprotective effect in males and a double neuroprotective/neurorestorative effect in females. | es_ES |
dc.description.sponsorship | Grant MINECOR20/P66 funded by MCIN/AEI/10.13039/501100011033. Predoctoral grants were given to G.B. by Programa Investigo by the European Union-Next Generation EU (PIFINVE22/15) and to M.C. by UPV/EHU (PIFBUR22/03). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/es/ | |
dc.subject | neonatal hypoxia–ischemia | es_ES |
dc.subject | endocannabinoid system | es_ES |
dc.subject | neuroprotection | es_ES |
dc.subject | neurogenesis | es_ES |
dc.title | URB447 Is Neuroprotective in Both Male and Female Rats after Neonatal Hypoxia–Ischemia and Enhances Neurogenesis in Females | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2024-02-09T15:06:59Z | |
dc.rights.holder | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/25/3/1607 | es_ES |
dc.identifier.doi | 10.3390/ijms25031607 | |
dc.departamentoes | Biología celular e histología | |
dc.departamentoes | Cirugía, radiología y medicina física | |
dc.departamentoeu | Zelulen biologia eta histologia | |
dc.departamentoeu | Kirurgia,erradiologia eta medikuntza fisikoa |
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Except where otherwise noted, this item's license is described as © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).