dc.contributor.author | Nori, Valeria | |
dc.contributor.author | Sinibaldi, Arianna | |
dc.contributor.author | Giorgianni, Giuliana | |
dc.contributor.author | Pesciaioli, Fabio | |
dc.contributor.author | Di Donato, Francesca | |
dc.contributor.author | Cocco, Emanuele | |
dc.contributor.author | Biancolillo, Alessandra | |
dc.contributor.author | Landa Álvarez, Aitor | |
dc.contributor.author | Carlone, Armando | |
dc.date.accessioned | 2024-04-10T17:24:47Z | |
dc.date.available | 2024-04-10T17:24:47Z | |
dc.date.issued | 2022-03-01 | |
dc.identifier.citation | Chemistry - A European Journal 28(24) : (2022) // Article ID e202104524 | es_ES |
dc.identifier.issn | 0947-6539 | |
dc.identifier.uri | http://hdl.handle.net/10810/66612 | |
dc.description.abstract | Moving from organic solvents to water is not always an easy task, especially when a lot of variables need to be screened. The development of an enantioselective enamine-catalysed Michael addition of acetaldehyde to nitroalkenes in water was developed by using a rational approach, via chemometrics-assisted ‘Design of Experiments’ (DoE) optimisation. This way it was possible to screen 9 different parameters, their interaction with each other, and the full chemical space, with minimum experiments in an efficient manner. | es_ES |
dc.description.sponsorship | G.G. is grateful to PON-DOT13OV2OC for an industrial Ph.D. fellowship. F.P. and A.B. thank PON-AIM grant number 1842894 for funding this research. A. L. thanks the University of the Basque Country UPV/EHU (UFIQOSYC11/22), Basque Government (GVgrant IT1236-19), and Ministerio de Ciencia e Innovación (grant PID2019-109633GBC21) for financial support. Open Access Funding provided by Università degli Studi dell′Aquila within the CRUI-CARE Agreement. Open Access Funding provided by Universita degli Studi dell'Aquila within the CRUI-CARE Agreement. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-VCH | es_ES |
dc.relation | info:eu-repo/grantAgreement/MCIN/PID2019-109633GBC21 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Acetaldehyde | es_ES |
dc.subject | Organocatalysis | es_ES |
dc.subject | Michael reaction | es_ES |
dc.subject | DoE | es_ES |
dc.title | DoE-driven development of an organocatalytic enantioselective addition of acetaldehyde to nitrostyrenes in water | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License | es_ES |
dc.relation.publisherversion | https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202104524 | es_ES |
dc.identifier.doi | 10.1002/chem.202104524 | |
dc.departamentoes | Química orgánica I | es_ES |
dc.departamentoeu | Kimika organikoa I | es_ES |