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DoE-driven development of an organocatalytic enantioselective addition of acetaldehyde to nitrostyrenes in water

dc.contributor.authorNori, Valeria
dc.contributor.authorSinibaldi, Arianna
dc.contributor.authorGiorgianni, Giuliana
dc.contributor.authorPesciaioli, Fabio
dc.contributor.authorDi Donato, Francesca
dc.contributor.authorCocco, Emanuele
dc.contributor.authorBiancolillo, Alessandra
dc.contributor.authorLanda Álvarez, Aitor
dc.contributor.authorCarlone, Armando
dc.date.accessioned2024-04-10T17:24:47Z
dc.date.available2024-04-10T17:24:47Z
dc.date.issued2022-03-01
dc.identifier.citationChemistry - A European Journal 28(24) : (2022) // Article ID e202104524es_ES
dc.identifier.issn0947-6539
dc.identifier.urihttp://hdl.handle.net/10810/66612
dc.description.abstractMoving from organic solvents to water is not always an easy task, especially when a lot of variables need to be screened. The development of an enantioselective enamine-catalysed Michael addition of acetaldehyde to nitroalkenes in water was developed by using a rational approach, via chemometrics-assisted ‘Design of Experiments’ (DoE) optimisation. This way it was possible to screen 9 different parameters, their interaction with each other, and the full chemical space, with minimum experiments in an efficient manner.es_ES
dc.description.sponsorshipG.G. is grateful to PON-DOT13OV2OC for an industrial Ph.D. fellowship. F.P. and A.B. thank PON-AIM grant number 1842894 for funding this research. A. L. thanks the University of the Basque Country UPV/EHU (UFIQOSYC11/22), Basque Government (GVgrant IT1236-19), and Ministerio de Ciencia e Innovación (grant PID2019-109633GBC21) for financial support. Open Access Funding provided by Università degli Studi dell′Aquila within the CRUI-CARE Agreement. Open Access Funding provided by Universita degli Studi dell'Aquila within the CRUI-CARE Agreement.es_ES
dc.language.isoenges_ES
dc.publisherWiley-VCHes_ES
dc.relationinfo:eu-repo/grantAgreement/MCIN/PID2019-109633GBC21es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAcetaldehydees_ES
dc.subjectOrganocatalysises_ES
dc.subjectMichael reactiones_ES
dc.subjectDoEes_ES
dc.titleDoE-driven development of an organocatalytic enantioselective addition of acetaldehyde to nitrostyrenes in wateres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs Licensees_ES
dc.relation.publisherversionhttps://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202104524es_ES
dc.identifier.doi10.1002/chem.202104524
dc.departamentoesQuímica orgánica Ies_ES
dc.departamentoeuKimika organikoa Ies_ES


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© 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License
Except where otherwise noted, this item's license is described as © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License