Brønsted Base-Catalyzed Enantioselective α-Functionalization of Carbonyl Compounds Involving π-Extended Enolates
dc.contributor.author | Oyarbide Garmendia, Juan Miguel | |
dc.contributor.author | Palomo Nicolau, Claudio | |
dc.date.accessioned | 2024-04-15T15:20:39Z | |
dc.date.available | 2024-04-15T15:20:39Z | |
dc.date.issued | 2023-11 | |
dc.identifier.citation | The Chemical Record 23(11) : (2023) // Article ID e202300164 | es_ES |
dc.identifier.issn | 1528-0691 | |
dc.identifier.issn | 1527-8999 | |
dc.identifier.uri | http://hdl.handle.net/10810/66686 | |
dc.description.abstract | Chiral Brønsted base (BB) catalyzed asymmetric transformations constitute an important tool for synthesis. A meaningful fraction of these transformations proceeds through transiently generated enolate intermediates, which display quite versatile reactivity against a variety of electrophiles. Some years ago, our group became interested in developing BB-catalyzed asymmetric reactions of enolizable carbonyl substrates that involve π-extended enolates in which, besides control of reaction diastereo and enantioselectivity, the site-selectivity control is an additional issue in most cases. In the examples covered in this account the opportunities deployed, and the challenges posed, by these methods are illustrated, with a focus on the generation of quaternary carbon stereocenters. In the way, new bifunctional BB catalysts as well as achiral templates were developed that may find further applications. | es_ES |
dc.description.sponsorship | We thank the University of the Basque Country UPV/EHU, Basque Government (EJ, grant IT-1583-22) and Agencia Estatal de Investigación (grant PID2019-109633GB-C21/AEI/10.13039/501100011033), Spain, for their continuous financial support. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | asymmetric catalysis | es_ES |
dc.subject | bifunctional catalysis | es_ES |
dc.subject | extended enolates | es_ES |
dc.subject | quaternary stereocenters | es_ES |
dc.subject | regioselectivity | es_ES |
dc.title | Brønsted Base-Catalyzed Enantioselective α-Functionalization of Carbonyl Compounds Involving π-Extended Enolates | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2023 The Authors. The Chemical Record published by The Chemical Society of Japan and Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/tcr.202300164 | es_ES |
dc.identifier.doi | 10.1002/tcr.202300164 | |
dc.departamentoes | Química orgánica I | es_ES |
dc.departamentoeu | Kimika organikoa I | es_ES |
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Except where otherwise noted, this item's license is described as © 2023 The Authors. The Chemical Record published by The Chemical Society of Japan and Wiley-VCH GmbH
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.