Müller glial cells located in the peripheral retina are more susceptible to high pressure: implications for glaucoma
dc.contributor.author | Pereiro Díez, Xandra ![]() | |
dc.contributor.author | Ruzafa Andrés, Noelia ![]() | |
dc.contributor.author | Azkargorta, Mikel | |
dc.contributor.author | Elortza, Felix | |
dc.contributor.author | Acera Osa, Arantxa | |
dc.contributor.author | Ambrósio, António Francisco | |
dc.contributor.author | Santiago, Ana Raquel | |
dc.contributor.author | Vecino Cordero, Elena ![]() | |
dc.date.accessioned | 2024-04-19T16:55:42Z | |
dc.date.available | 2024-04-19T16:55:42Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Cell & Bioscience 14 : (2024) // Article ID 5 | es_ES |
dc.identifier.issn | 2045-3701 | |
dc.identifier.uri | http://hdl.handle.net/10810/66820 | |
dc.description.abstract | Background Glaucoma, a progressive neurodegenerative disease, is a leading cause of irreversible vision loss worldwide. This study aims to elucidate the critical role of Müller glia (MG) in the context of retinal ganglion cell (RGC) death, particularly focusing on the influence of peripheral MG sensitivity to high pressure (HP). Methods Co-cultures of porcine RGCs with MG were isolated from both the central and peripheral regions of pig retinas and subjected to both normal and HP conditions. Mass spectrometry analysis of the MG-conditioned medium was conducted to identify the proteins released by MG under all conditions. Results Peripheral MG were found to secrete a higher quantity of neuroprotective factors, effectively promoting RGC survival under normal physiological conditions. However, under HP conditions, co-cultures with peripheral MG exhibited impaired RGC survival. Moreover, under HP conditions, peripheral MG significantly upregulated the secretion of proteins associated with apoptosis, oxidative stress, and inflammation. Conclusions This study provides robust evidence suggesting the involvement of MG in RGC death in glaucoma, thus paving the way for future therapeutic investigations. | es_ES |
dc.description.sponsorship | This research was supported by: Grupos Consolidados Gobierno Vasco IT1510-22 (EV), ELKARTEK KK-2019/00086 (EV), MINECO-Retos PID2019-111139RB-I00 (EV), PIBA 2020_1_0026 (EV), Gobierno Vasco postdoctoral grant POS_2022_2_0007 (XP). UPV/EHU postdoctoral grant (NR). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BMC | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-111139RB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Müller glia | es_ES |
dc.subject | retinal ganglion cells | es_ES |
dc.subject | glaucoma | es_ES |
dc.subject | retina | es_ES |
dc.subject | neurodegeneration | es_ES |
dc.title | Müller glial cells located in the peripheral retina are more susceptible to high pressure: implications for glaucoma | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-023-01186-1 | es_ES |
dc.identifier.doi | 10.1186/s13578-023-01186-1 | |
dc.departamentoes | Biología celular e histología | es_ES |
dc.departamentoeu | Zelulen biologia eta histologia | es_ES |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.