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dc.contributor.authorMilton Laskibar, Iñaki
dc.contributor.authorMarcos Zambrano, Laura Judith
dc.contributor.authorGómez Zorita, Saioa
dc.contributor.authorCarrillo de Santa Pau, Enrique
dc.contributor.authorFernández Quintela, Alfredo ORCID
dc.contributor.authorMartínez Hernández, José Alfredo
dc.contributor.authorPortillo Baquedano, María Puy ORCID
dc.date.accessioned2024-04-29T17:59:48Z
dc.date.available2024-04-29T17:59:48Z
dc.date.issued2022-04
dc.identifier.citationGut Microbiome 3 : (2022) // Article ID e5es_ES
dc.identifier.issn2632-2897
dc.identifier.urihttp://hdl.handle.net/10810/66933
dc.description.abstractConsumption of high-energy-yielding diets, rich in fructose and lipids, is a factor contributing to the current increase in non-alcoholic fatty liver disease prevalence. Gut microbiota composition and short-chain fatty acids (SCFAs) production alterations derived from unhealthy diets are considered putative underlying mechanisms. This study aimed to determine relationships between changes in gut microbiota composition and SCFA levels by comparing rats featuring diet-induced steatohepatitis with control counterparts fed a standard diet. A high-fat high-fructose (HFHF) feeding induced higher body, liver and mesenteric adipose tissue weights, increased liver triglyceride content and serum transaminase, glucose, non-HDL-c and MCP-1 levels. Greater liver malondialdehyde levels and glutathione peroxidase activity were also observed after feeding the hypercaloric diet. Regarding gut microbiota composition, a lowered diversity and increased abundances of bacteria from the Clostridium sensu stricto 1, Blautia, Eubacterium coprostanoligenes group, Flavonifractor, and UBA1819 genera were found in rats featuring diet-induced steatohepatitis, as well as higher isobutyric, valeric and isovaleric acids concentrations. These results suggest that hepatic alterations produced by a hypercaloric HFHF diet may be related to changes in overall gut microbiota composition and abundance of specific bacteria. The shift in SCFA levels produced by this unbalanced diet cannot be discarded as potential mediators of the reported hepatic and metabolic alterations.es_ES
dc.description.sponsorshipI.M.-L. acknowledges financial support from the Juan de la Cierva Programme-Training Grants of the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades (FJC2019-038925-I). L.J.M.-Z. has a Juan de la Cierva Grant (IJC2019-042188-I) from the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades. This research was funded by the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (grant number AGL-2015-65719-R MINECO/FEDER, UE), Instituto de Salud Carlos III CIBERobn (grant number CB12/03/30007) and University of the Basque Country (grant number GIU 18/173).es_ES
dc.language.isoenges_ES
dc.publisherCambridge University Presses_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/FJC2019-038925-Ies_ES
dc.relationinfo:eu-repo/grantAgreement/MICIU/IJC2019-042188-Ies_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectnon-alcoholic steatohepatitises_ES
dc.subjectrates_ES
dc.subjectmicrobiotaes_ES
dc.subjecthigh-fat high-fructose dietes_ES
dc.subjectshort-chain fatty acidses_ES
dc.titleInvolvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructosees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly citedes_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.cambridge.org/core/journals/gut-microbiome/article/involvement-of-microbiota-and-shortchain-fatty-acids-on-nonalcoholic-steatohepatitis-when-induced-by-feeding-a-hypercaloric-diet-rich-in-saturated-fat-and-fructose/9B9899B87CAC62F834BA48B7960DF526es_ES
dc.identifier.doi10.1017/gmb.2022.2
dc.departamentoesFarmacia y ciencias de los alimentoses_ES
dc.departamentoeuFarmazia eta elikagaien zientziakes_ES


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© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society. This is an Open Access article, distributed
under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted
re-use, distribution, and reproduction in any medium, provided the original work is properly cited
Except where otherwise noted, this item's license is described as © The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited