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dc.contributor.authorGunatilake, Udara Bimendra
dc.contributor.authorCaballé Ábalos, Adriana
dc.contributor.authorGarcía Rey, Sandra
dc.contributor.authorMercader Ruiz, Jon
dc.contributor.authorBasabe Desmonts, Lourdes ORCID
dc.contributor.authorBenito López, Fernando ORCID
dc.date.accessioned2024-05-02T18:04:06Z
dc.date.available2024-05-02T18:04:06Z
dc.date.issued2023-12
dc.identifier.citationAdvanced Materials Interface 10(34) : (2023) // Article ID 2202459es_ES
dc.identifier.issn2196-7350
dc.identifier.issn2196-7350
dc.identifier.urihttp://hdl.handle.net/10810/67340
dc.description.abstractRemotely handled miniaturized colorimetric sensor platforms with multiple functionalities are able to mimic conventional laboratory operations with reduced assets. The integration of a magnetic phase in a miniaturized hydrogel sensor system allows the manipulation of the sensor, under a magnetic field, in a programmable manner. However, dark color interferences from conventional magnetic phases (Fe3O4, Fe2O3, and Fe micro/nanoparticles) affect the signal readout, hindering the colorimetric response. Therefore, a novel Janus bead configuration is introduced and tested by the localized incorporation of ferromagnetic iron microparticles into a TiO2 nanotubes/alginate hydrogel bead biosystem, under an applied magnetic field. The so-called hydrogel Janus bead shows both, magnetic translocation and biosensing properties in the same bead. These beads are used for the direct colorimetric analysis of biomarkers in blood. The surface of the Janus bead prevents the biofouling of red blood cells, keeping the sensor surface clean for accurate optical colorimetric analysis. Moreover, the external magnetic manipulation of the bead permits precise control of the time and position of the bead in the sample. Therefore, multiple functionalities are presented by a single magnetic TiO2 nanotubes/alginate Janus bead such as actuation, low biofouling, and sensing, positioning this technology as a truly Lab-in-a-Bead System.es_ES
dc.description.sponsorshipThe authors acknowledge the MaMi project, funded by the European Union's Horizon 2020 research and Innovation Programme under grant agreement no. 766007. The authors acknowledge funding support from the “Ministerio de Ciencia y Educación de España” under grant PID2020-120313GB-I00/AIE/10.13039/501100011033 y por FEDER una manera de hacer Europa, Gobierno Vasco Dpto. Educación for the consolidation of the research groups (IT1633-22) and Proyecto de Investigación Fundamental Colaborativa – Investigación Fundamental ELKARTEK: KK-2023/00070. Special thanks to (SGIker) of the University of the Basque Country (UPV/EHU) and Dr. Rafael Morales for SQUID characterization.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/766007es_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2020-120313GB-I00es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectbloodes_ES
dc.subjectcolorimetric glucosees_ES
dc.subjectJanus beadses_ES
dc.subjectlab-in-a-beades_ES
dc.subjectmagnetic hydrogelses_ES
dc.subjectsensor scaffoldses_ES
dc.titleLab-in-a-Bead: Magnetic Janus Bead Probe for the Detection of Biomarkers in Bloodes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH. This is an open access article under the terms of theCreative Commons Attribution License, which permits use, distributionand reproduction in any medium, provided the original work is properlycited.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/admi.202202459es_ES
dc.identifier.doi10.1002/admi.202202459
dc.contributor.funderEuropean Commission
dc.departamentoesQuímica analíticaes_ES
dc.departamentoesZoología y biología celular animales_ES
dc.departamentoeuKimika analitikoaes_ES
dc.departamentoeuZoologia eta animalia zelulen biologiaes_ES


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© 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH. This is an open access article under the terms of theCreative Commons Attribution License, which permits use, distributionand reproduction in any medium, provided the original work is properlycited.
Except where otherwise noted, this item's license is described as © 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH. This is an open access article under the terms of theCreative Commons Attribution License, which permits use, distributionand reproduction in any medium, provided the original work is properlycited.