dc.contributor.author | Yokoyama, Yoshie | |
dc.contributor.author | Jelenkovic Moreno, Aline | |
dc.contributor.author | Hur, Yoon-Mi | |
dc.contributor.author | Sund, Reijo | |
dc.contributor.author | Fagnani, Corrado | |
dc.contributor.author | Stazi, Maria A | |
dc.contributor.author | Brescianini, Sonia | |
dc.contributor.author | Ji, Fuling | |
dc.contributor.author | Ning, Feng | |
dc.contributor.author | Pang, Zengchang | |
dc.contributor.author | Knafo-Noam, Ariel | |
dc.contributor.author | Mankuta, David | |
dc.contributor.author | Abramson, Lior | |
dc.contributor.author | Rebato, Esther | |
dc.contributor.author | Hopper, John L | |
dc.contributor.author | Cutler, Tessa L | |
dc.contributor.author | Saudino, Kimberly J | |
dc.contributor.author | Nelson, Tracy L | |
dc.contributor.author | Whitfield, Keith E | |
dc.contributor.author | Corley, Robin P | |
dc.contributor.author | Huibregtse, Brooke M | |
dc.contributor.author | Derom, Catherine A | |
dc.contributor.author | Vlietinck, Robert F | |
dc.contributor.author | Loos, Ruth JF | |
dc.contributor.author | Llewellyn, Clare H | |
dc.contributor.author | Fisher, Abigail | |
dc.contributor.author | Bjerregaard-Andersen, Morten | |
dc.contributor.author | Beck-Nielsen, Henning | |
dc.contributor.author | Sodemann, Morten | |
dc.contributor.author | Krueger, Robert F | |
dc.contributor.author | McGue, Matt | |
dc.contributor.author | Pahlen, Shandell | |
dc.contributor.author | Bartels, Meike | |
dc.contributor.author | Van Beijsterveldt, Catharina E M | |
dc.contributor.author | Willemsen, Gonneke | |
dc.contributor.author | Harris, Jennifer R | |
dc.contributor.author | Brandt, Ingunn | |
dc.contributor.author | Nilsen, Thomas S | |
dc.contributor.author | Craig, Jeffrey M | |
dc.contributor.author | Saffery, Richard | |
dc.contributor.author | Dubois, Lise | |
dc.contributor.author | Boivin, Michel | |
dc.contributor.author | Brendgen, Mara | |
dc.contributor.author | Dionne, Ginette | |
dc.contributor.author | Vitaro, Frank | |
dc.contributor.author | Haworth, Claire M A | |
dc.contributor.author | Plomin, Robert | |
dc.contributor.author | Bayasgalan, Gombojav | |
dc.contributor.author | Narandalai, Danshiitsoodol | |
dc.contributor.author | Rasmussen, Finn | |
dc.contributor.author | Tynelius, Per | |
dc.contributor.author | Tarnoki, Adam D | |
dc.contributor.author | Tarnoki, David L | |
dc.contributor.author | Ooki, Syuichi | |
dc.contributor.author | Rose, Richard J | |
dc.contributor.author | Pietiläinen, Kirsi H | |
dc.contributor.author | Sørensen, Thorkild I A | |
dc.contributor.author | Boomsma, Dorret I | |
dc.contributor.author | Kaprio, Jaakko | |
dc.contributor.author | Silventoinen, Karri | |
dc.date.accessioned | 2024-05-28T15:12:26Z | |
dc.date.available | 2024-05-28T15:12:26Z | |
dc.date.issued | 2018-05-19 | |
dc.identifier.citation | International Journal of Epidemiology 47(4) : 1195-1206 (2018) | es_ES |
dc.identifier.issn | 0300-5771 | |
dc.identifier.issn | 1464-3685 | |
dc.identifier.uri | http://hdl.handle.net/10810/68226 | |
dc.description.abstract | Background: The genetic architecture of birth size may differ geographically and over
time. We examined differences in the genetic and environmental contributions to birthweight,
length and ponderal index (PI) across geographical-cultural regions (Europe,
North America and Australia, and East Asia) and across birth cohorts, and how gestational
age modifies these effects.
Methods: Data from 26 twin cohorts in 16 countries including 57 613 monozygotic and dizygotic
twin pairs were pooled. Genetic and environmental variations of birth size were
estimated using genetic structural equation modelling.
Results: The variance of birthweight and length was predominantly explained by shared
environmental factors, whereas the variance of PI was explained both by shared and
unique environmental factors. Genetic variance contributing to birth size was small.
Adjusting for gestational age decreased the proportions of shared environmental variance and increased the propositions of unique environmental variance. Genetic variance
was similar in the geographical-cultural regions, but shared environmental variance
was smaller in East Asia than in Europe and North America and Australia. The total variance
and shared environmental variance of birth length and PI were greater from the
birth cohort 1990–99 onwards compared with the birth cohorts from 1970–79 to 1980–89.
Conclusions: The contribution of genetic factors to birth size is smaller than that of
shared environmental factors, which is partly explained by gestational age. Shared environmental
variances of birth length and PI were greater in the latest birth cohorts and
differed also across geographical-cultural regions. Shared environmental factors are important
when explaining differences in the variation of birth size globally and over time. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | birthweight | es_ES |
dc.subject | birth length | es_ES |
dc.subject | ponderal index | es_ES |
dc.subject | twins | es_ES |
dc.subject | genetics | es_ES |
dc.subject | pooled studies | es_ES |
dc.title | Genetic and environmental factors affecting birth size variation: a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2018; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association | es_ES |
dc.relation.publisherversion | https://academic.oup.com/ije/article/47/4/1195/4999873 | es_ES |
dc.identifier.doi | 10.1093/ije/dyy081 | |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |