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Design, synthesis and cytotoxic evaluation of diphenyl(quinolin-8-yl)phosphine oxides

dc.contributor.authorSelas Lanseros, Asier
dc.contributor.authorRamírez, Guillermo
dc.contributor.authorPalacios Gambra, Francisco Javier ORCID
dc.contributor.authorAlonso Pérez, Concepción Estibaliz ORCID
dc.date.accessioned2024-05-28T15:45:19Z
dc.date.available2024-05-28T15:45:19Z
dc.date.issued2021-04
dc.identifier.citationTetrahedron Letters 70 : (2021) // Article ID 153019es_ES
dc.identifier.issn0040-4039
dc.identifier.issn1873-3581
dc.identifier.urihttp://hdl.handle.net/10810/68229
dc.description.abstractA new strategy is reported for the synthesis of quinolinylphosphine oxides via the Povarov reaction between phosphorous aldimines and acetylenes. Moreover, these compounds were studied for in vitro cytotoxicity on a human lung alveolus adenocarcinoma (A 549) cell line, demonstrating strong inhibition of cell growth.es_ES
dc.description.sponsorshipFinancial support from the Ministerio de Ciencia, Innovación y Universidades (MCIU), Agencia Estatal de Investigación (AEI) y Fondo Europeo de Desarrollo Regional (FEDER; RTI2018-101818-B-I00, UE) and by Gobierno Vasco, Universidad del País Vasco (GV, IT 992-16; UPV) is gratefully acknowledged. Technical support provided by IZO-SGI, SGIker (UPV/EHU, MICINN, GV/EJ, ERDF and ESF) is gratefully acknowledged. AS thanks the Basque Government for a formation contract.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationinfo:eu-repo/grantAgreement/MICIU/RTI2018-101818-B-I00es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectPovarov reactiones_ES
dc.subjectaromatizationes_ES
dc.subjectquinolinylphosphine oxideses_ES
dc.subjectantiproliferative effectes_ES
dc.titleDesign, synthesis and cytotoxic evaluation of diphenyl(quinolin-8-yl)phosphine oxideses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S004040392100215Xes_ES
dc.identifier.doi10.1016/j.tetlet.2021.153019
dc.departamentoesQuímica orgánica Ies_ES
dc.departamentoeuKimika organikoa Ies_ES


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© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).