dc.contributor.author | Jelenkovic Moreno, Aline | |
dc.contributor.author | Bogl, Leonie H. | |
dc.contributor.author | Rose, Richard J. | |
dc.contributor.author | Kangas, Antti J. | |
dc.contributor.author | Soininen, Pasi | |
dc.contributor.author | Ala-Korpela, Mika | |
dc.contributor.author | Kaprio, Jaakko | |
dc.contributor.author | Silventoinen, Karri | |
dc.date.accessioned | 2024-05-31T10:09:23Z | |
dc.date.available | 2024-05-31T10:09:23Z | |
dc.date.issued | 2014-01-21 | |
dc.identifier.citation | Atherosclerosis 233(2) : 394-402 (2014) | es_ES |
dc.identifier.issn | 0021-9150 | |
dc.identifier.issn | 1879-1484 | |
dc.identifier.uri | http://hdl.handle.net/10810/68294 | |
dc.description.abstract | Objective
Little is known about the associations of serum fatty acids with lipoprotein profile and the underlying genetic and environmental etiology of these relationships. We aimed to analyze the phenotypic association of serum n-6 and n-3 polyunsaturated (PUFAs), monounsaturated (MUFAs) and saturated (SFAs) fatty acids (relative proportion to total fatty acids) with lipids and lipoproteins, and to quantify common genetic and environmental factors determining their covariation.
Methods
Two cohorts of healthy Finnish twins were assessed in young adulthood. Data were available for 1269 individual twins including 561 complete pairs. Serum metabolites were measured by nuclear magnetic resonance spectroscopy. Bivariate quantitative genetic models were used to decompose the phenotypic covariance between the pairs of traits into genetic and environmental components.
Results
Among the strongest correlations observed, serum total n-6 PUFAs and linoleic acid were inversely (max. r = −0.65) and MUFAs positively (max. r = 0.63) correlated with triglycerides and very low-density lipoprotein (VLDL) particle concentration, particularly with large VLDL (for n-6 PUFAs) and medium VLDL (for MUFAs). Genetic factors significantly contributed to their covariance with bivariate heritability estimates ranging from 44% to 56% for n-6 PUFAs and 58% to 66% for MUFAs. Genetic correlations with lipid traits were moderate to high (max. rA = −0.59 and 0.70 for n-6 PUFAs and MUFAs, respectively). Statistically significant, but substantially weaker phenotypic correlations of total n-3 PUFAs, docosahexaenoic acid (DHA) and SFAs with lipoprotein profile were not decomposed into their genetic and environmental components.
Conclusion
Shared genetic factors are important in explaining why higher concentrations of serum n-6 PUFAs and lower concentrations of serum MUFAs strongly associate with lower triglyceride and VLDL particle concentrations. | es_ES |
dc.description.sponsorship | This work was supported by a Postdoctoral fellowship from the Basque Government's Department of Education, Universities and Research (DEUI) to AJ, and also by Doctoral Programs of Public Health and grants from the Juho Vainio, Yrjö Jahnsson, Jenny and Antti Wihuri and Biomedicum Helsinki Foundations. Data collection in FinnTwin12 and FinnTwin16 was supported by National Institute of Alcohol Abuse and Alcoholism (grant numbers AA08315, AA12502, AA00145, and AA09203 to RJR) and the Academy of Finland (grant numbers 205585 and 141054 to JK and 266592 to KS). This work was also supported by the Academy of Finland (grant number 137870 to PS), the Sigrid Jusélius Foundation (MAK), the Finnish Funding Agency for Technology – TEKES (MAK) and the Strategic Research Funding from the University of Oulu (MAK). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | |
dc.subject | serum fatty acids | es_ES |
dc.subject | lipoprotein profile | es_ES |
dc.subject | twins | es_ES |
dc.subject | genetic pleiotropy | es_ES |
dc.subject | environmental factors | es_ES |
dc.title | Association between serum fatty acids and lipoprotein subclass profile in healthy young adults: exploring common genetic and environmental factors | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0021915014000410 | es_ES |
dc.identifier.doi | 10.1016/j.atherosclerosis.2013.12.053 | |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |