Revealing novel biomarkers for diagnosing chronic kidney disease in pediatric patients
dc.contributor.author | Benito Cid, Sandra | |
dc.contributor.author | Unceta Zaballa, Nora | |
dc.contributor.author | Maciejczyk, Mateusz | |
dc.contributor.author | Sánchez Ortega, Alicia | |
dc.contributor.author | Taranta-Janusz, Katarzyna | |
dc.contributor.author | Szulimowska, Julita | |
dc.contributor.author | Zalewska, Anna | |
dc.contributor.author | Andrade, Fernando | |
dc.contributor.author | Gómez Caballero, Alberto | |
dc.contributor.author | Dubiela, Pawel | |
dc.contributor.author | Barrio Díez-Caballero, Ramón José | |
dc.date.accessioned | 2024-06-25T16:58:01Z | |
dc.date.available | 2024-06-25T16:58:01Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Scientific Reports 14 : (2024) // Article ID 11549 | es_ES |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10810/68670 | |
dc.description.abstract | Pediatric chronic kidney disease (CKD) is a clinical condition characterized by progressive renal function deterioration. CKD diagnosis is based on glomerular filtration rate, but its reliability is limited, especially at the early stages. New potential biomarkers (citrulline (CIT), symmetric dimethylarginine (SDMA), S-adenosylmethionine (SAM), n-butyrylcarnitine (nC4), cis-4-decenoylcarnitine, sphingosine-1-phosphate and bilirubin) in addition to creatinine (CNN) have been proposed for early diagnosis. To verify the clinical value of these biomarkers we performed a comprehensive targeted metabolomics study on a representative cohort of CKD and healthy pediatric patients. Sixty-seven children with CKD and forty-five healthy children have been enrolled in the study. Targeted metabolomics based on liquid chromatography-triple quadrupole mass spectrometry has been used for serum and plasma samples analysis. Univariate data analysis showed statistically significant differences (p < 0.05) in the concentration of CNN, CIT, SDMA, and nC4 among healthy and CKD pediatric patients. The predictive ability of the proposed biomarkers was also confirmed through specificity and sensitivity expressed in Receiver Operating Characteristic curves (AUC = 0.909). In the group of early CKD pediatric patients, AUC of 0.831 was obtained, improving the diagnostic reliability of CNN alone. Moreover, the models built on combined CIT, nC4, SDMA, and CNN allowed to distinguish CKD patients from healthy control regardless of blood matrix type (serum or plasma). Our data demonstrate potential biomarkers in the diagnosis of early CKD stages. | es_ES |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Science and Innovation (PID2022-138266NB-I00); the Basque Government (Research Groups of the Basque University System, Project No IT 1492–22); the Vice-Rectorate for Research of the University of the Basque Country UPV/EHU (DOKBERRI2018-I postdoctoral grant, DOCREC18/27); the Medical University of Bialystok, Poland (grant number: SUB/1/DN/19/004/1141 and SUB/1/DN/21/002/3330). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2022-138266NB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.title | Revealing novel biomarkers for diagnosing chronic kidney disease in pediatric patients | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons. org/ licenses/ by/4. 0/ | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-024-62518-w | es_ES |
dc.identifier.doi | 10.1038/s41598-024-62518-w | |
dc.departamentoes | Química analítica | es_ES |
dc.departamentoeu | Kimika analitikoa | es_ES |
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