New Origins of Yeast, Plant and Bacterial-Derived Extracellular Vesicles to Expand and Advance Compound Delivery
dc.contributor.author | Fernández Rhodes, María | |
dc.contributor.author | Lorca, Cristina | |
dc.contributor.author | Lisa, Julia | |
dc.contributor.author | Batalla, Iolanda | |
dc.contributor.author | Ramos Miguel, Alfredo | |
dc.contributor.author | Gallart Palau, Xavier | |
dc.contributor.author | Serra, Aida | |
dc.date.accessioned | 2024-08-01T08:52:25Z | |
dc.date.available | 2024-08-01T08:52:25Z | |
dc.date.issued | 2024-06-28 | |
dc.identifier.citation | International Journal of Molecular Sciences 25(13) : (2024) // Article ID 7151 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10810/69113 | |
dc.description.abstract | Extracellular vesicles (EVs) constitute a sophisticated molecular exchange mechanism highly regarded for their potential as a next-generation platform for compound delivery. However, identifying sustainable and biologically safe sources of EVs remains a challenge. This work explores the emergence of novel sources of plant and bacterial-based EVs, such as those obtained from food industry by-products, known as BP-EVs, and their potential to be used as safer and biocompatible nanocarriers, addressing some of the current challenges of the field. These novel sources exhibit remarkable oral bioavailability and biodistribution, with minimal cytotoxicity and a selective targeting capacity toward the central nervous system, liver, and skeletal tissues. Additionally, we review the ease of editing these recently uncovered nanocarrier-oriented vesicles using common EV editing methods, examining the cargo-loading processes applicable to these sources, which involve both passive and active functionalization methods. While the primary focus of these novel sources of endogenous EVs is on molecule delivery to the central nervous system and skeletal tissue based on their systemic target preference, their use, as reviewed here, extends beyond these key applications within the biotechnological and biomedical fields. | es_ES |
dc.description.sponsorship | This research was funded by the National Institute of Health/Instituto de Salud Carlos III-ISCIII, Spain (PI22/00443 to X.G.-P.) (grant co-funded by the European Union), and the Ministry of Science and Innovation-MCIN, Spain and the National Research Council/Agencia Estatal de Investigación-AEI, Spain (PID2020-114885RB-C21 to A.S.) funded by MCIN/AEI/10.13039/501100011033. This research was also co-financed by the Spanish Ministry of Science and Innovation with funds from the European Union NextGenerationEU; from the Recovery, Transformation and Resilience Plan (PRTR-C17.I1); and from the Autonomous Community of Catalonia within the framework of the Biotechnology Plan Applied to Health ((EVBRAINTARGET-Y7340-ACPPCCOL007 to X.G.-P., A.S. & A.R.-M.) coordinated by the Institute for Bioengineering of Catalonia (IBEC)); the Diputació de Lleida, Spain (PIRS22/03 to X.G.-P. & I.B. and PIRS23/02 to A.S.) ‘La Força dels Municipis’; and the Catalan Research Council-AGAUR (2023 LLAV 00056 to X.G.-P. & 2022 DI 100 to X.G.-P.). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-114885RB-C21 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/es/ | |
dc.subject | extracellular vesicles | es_ES |
dc.subject | food industry by-products | es_ES |
dc.subject | drug loading | es_ES |
dc.subject | editing | es_ES |
dc.subject | drug delivery | es_ES |
dc.title | New Origins of Yeast, Plant and Bacterial-Derived Extracellular Vesicles to Expand and Advance Compound Delivery | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2024-07-12T12:42:32Z | |
dc.rights.holder | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/25/13/7151 | es_ES |
dc.identifier.doi | 10.3390/ijms25137151 | |
dc.departamentoes | Farmacología | |
dc.departamentoeu | Farmakologia |
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Except where otherwise noted, this item's license is described as © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).