dc.contributor.author | Díez Villalba, Ander | |
dc.contributor.author | Arrieta Aguirre, Inés | |
dc.contributor.author | Carrano, Giulia | |
dc.contributor.author | Fernández de Larrinoa Santamaría, Iñigo | |
dc.contributor.author | Moragues Tosantos, María Dolores | |
dc.date.accessioned | 2024-08-08T10:17:14Z | |
dc.date.available | 2024-08-08T10:17:14Z | |
dc.date.issued | 2024-08 | |
dc.identifier.citation | Vaccine 42(20) : (2024) // Article ID 125990 | es_ES |
dc.identifier.issn | 1873-2518 | |
dc.identifier.uri | http://hdl.handle.net/10810/69226 | |
dc.description.abstract | Candida albicans can cause superficial or systemic infections in humans, particularly in immunocompromised individuals. Vaccination strategies targeting specific antigens of C. albicans have shown promise in providing protection against invasive candidiasis. This study aimed to evaluate the immuno-protective capacity of a KLH conjugated complex peptide, 3P-KLH, containing epitopes from C. albicans antigens Als3, Hwp1, and Met6 in a murine model of hematogenously induced candidiasis. Mice immunized with 3P-KLH raised a specific antibody response, and protection against C. albicans infection was assessed. Immunized mice exhibited significantly lower fungal load in their kidneys compared to the control group. Moreover, 37.5 % of immunized mice survived 21 days after the infection, while all control animals died within the first nine days. These findings suggest that the 3P-KLH complex peptide, targeting C. albicans key antigens, elicits a protective immune response and reduces the severity of systemic Candida infection. In addition, the high binding affinity of the selected epitopes with MHC II alleles further supports the potential immunogenicity of this peptide in humans. This research provides insights into the development of novel immunotherapeutic approaches against invasive candidiasis. | es_ES |
dc.description.sponsorship | Funding for this work was provided by the University of the Basque Country UPV/EHU (GIU21/017) and the Basque Government (IT913-16). A. D. was supported by Fundación Jesus de Gangoiti Barrera. G. C. was supported by a Department of Education, Universities and Research of the Basque Country fellowship (PRE_2013_562). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Candida vaccine | es_ES |
dc.subject | epitopes | es_ES |
dc.subject | hematogenously induced candidiasis | es_ES |
dc.subject | Als3 | es_ES |
dc.subject | Met6 | es_ES |
dc.subject | Hwp1 | es_ES |
dc.title | A novel Candida albicans Als3, Hwp1 and Met6 derived complex peptide protects mice against hematogenously induced candidiasis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0264410X24005978 | es_ES |
dc.identifier.doi | 10.1016/j.vaccine.2024.05.038 | |
dc.departamentoes | Enfermería | es_ES |
dc.departamentoes | Inmunología, microbiología y parasitología | es_ES |
dc.departamentoes | Química aplicada | es_ES |
dc.departamentoeu | Erizaintza | es_ES |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia | es_ES |
dc.departamentoeu | Kimika aplikatua | es_ES |