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dc.contributor.authorHijona Muruamendiaraz, Elizabeth
dc.contributor.authorHijona Muruamendiaraz, Lander
dc.contributor.authorArenas Mirave, Juan Ignacio
dc.contributor.authorBujanda Fernández de Pierola, Luis ORCID
dc.date.accessioned2012-04-17T16:25:13Z
dc.date.available2012-04-17T16:25:13Z
dc.date.issued2010
dc.identifier.citationMediators of Inflammation 2010 : (2010) // Article ID 837419es
dc.identifier.issn0962-9351
dc.identifier.issn1466-1861
dc.identifier.urihttp://hdl.handle.net/10810/7350
dc.description7 p.es
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is rapidly becoming a world-wide public health problem. NAFLD represents a spectrum of disease ranging from “simple steatosis”, which is considered relatively benign, to nonalcoholic steatohepatitis and to NAFLD-associated cirrhosis and end-stage liver disease. The etiology of NAFLD and its progression is complex and remains incompletely understood. The progression of the disease involves many factors. Apart from the two hits, the accumulation of TG and the development of fibrosis and necroinflammatory processes, exit numerous molecules associated with these two hits. Among them we can highlight the pro-inflammatory molecules and adiponectins. This review focuses on the growing evidence from both experimental and human studies suggesting a central role of cytokines in the pathogenesis of NAFLD. We review the role of cytokines as key regulators of insulin sensitivity and hepatic lipid overloading, liver injury and inflammation, and fibrosis with an emphasis on potential therapeutic implications.es
dc.description.sponsorshipCIBEREHD is funded by the Instituto de Salud Carlos III, from the Spanish Ministry of Healthes
dc.language.isoenges
dc.publisherHindawi Publishing Corporationes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectnonalcoholic fatty liveres
dc.subjectperoxisomal beta-oxidationes
dc.subjecttype-2 diabetic patientses
dc.subjectnecrosis factor alphaes
dc.subjectinsulin resistancees
dc.subjectmetabolic syndromees
dc.subjectmitochondrial dysfunctiones
dc.subjectadipose tissuees
dc.titleInflammatory Mediators of Hepatic Steatosises
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holderCopyright © 2010 Elizabeth Hijona et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.es
dc.relation.publisherversionhttp://www.hindawi.com/journals/mi/2010/837419/es
dc.identifier.doi10.1155/2010/837419
dc.departamentoesMedicinaes_ES
dc.departamentoeuMedikuntzaes_ES
dc.subject.categoriaCELL BIOLOGY
dc.subject.categoriaIMMUNOLOGY AND MICROBIOLOGY


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