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Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review
(Elsevier, 2022-01)
[EN] Bipolar disorder (BD) might be associated with higher infection rates of coronavirus disease (COVID-19) which in turn could result in worsening the clinical course and outcome. This may be due to a high prevalence of ...
Autophagy and phagocytosis: functional relationship in microglia.
(2022-07-21)
La microglía es el macrófago del cerebro, en constante vigilancia del parénquima cerebral para garantizar el mantenimiento de la homeostasis tisular. La microglía es ampliamente conocida por supapel como mediadora de la ...
Combining MRI and clinical data to detect high relapse risk after the first episode of psychosis.
(Nature, 2022)
Detecting patients at high relapse risk after the first episode of psychosis (HRR-FEP) could help the clinician adjust the preventive treatment. To develop a tool to detect patients at HRR using their baseline clinical and ...
Recombinant Integrin β1 Signal Peptide Blocks Gliosis Induced by Aβ Oligomers
(MDPI, 2022-05-20)
Glial cells participate actively in the early cognitive decline in Alzheimer’s disease (AD) pathology. In fact, recent studies have found molecular and functional abnormalities in astrocytes and microglia in both animal ...
Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females
(Frontiers Media, 2022-10)
BackgroundDeficits in psychosocial functioning are present in the early stages of psychosis. Several factors, such as premorbid adjustment, neurocognitive performance, and cognitive reserve (CR), potentially influence ...
Targeting the Ubiquitin-Proteasome System in Limb-Girdle Muscular Dystrophy With CAPN3 Mutations
(Frontiers Media, 2022)
[EN] LGMDR1 is caused by mutations in the CAPN3 gene that encodes calpain 3 (CAPN3), a non-lysosomal cysteine protease necessary for proper muscle function. Our previous findings show that CAPN3 deficiency leads to reduced ...
Generation of new LGMDR1 models with CRISPR/Cas9 and studies to expand insight into the disease.
(2022-11-25)
La LGMDR1 es la forma más común de las distrofias musculares de cinturas, y está causada por mutaciones en el gen CAPN3. Este gen codifica la proteína calpaína 3, una proteasa no lisosomal que se expresa principalmente en ...
Kirolarien irudi-nahasmenduen azterketa eta dopinaren eragina kirolariengan
(2022-11-14)
Se ha analizado mediante revisión sistemática, el riesgo de desarrollar trastornos de la conducta alimentaria y dismorfia muscular en dos estudios. Tanto el primer estudio como el segundo, revisan estudios de intervención ...
Efficacy and safety clinical trial with efavirenz in patients diagnosed with adult Niemann-pick type C with cognitive impairment
(Wolters Kluwer Health, 2022-12)
Background:Niemann-Pick disease Type C (NPC) is a genetic, incurable, neurodegenerative disorder. This orphan disease is most frequently caused by mutations in the NPC1 protein, resulting in intralysossomal cholesterol ...
SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex
(BMC, 2022-12)
Antisense oligonucleotide (ASO) therapy for neurological disease has been successful in clinical settings and its potential has generated hope for Alzheimer's disease (AD). We previously described that ablating SNCA encoding ...