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Antioxidant defense system and family environment in adolescents with family history of psychosis

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Date
2012-11-16
Author
González Pinto Arrillaga, Ana María ORCID
Martínez Cengotitabengoa, Mónica ORCID
Arango, Celso
Baeza, Inmaculada
Otero Cuesta, Soraya
Graell Berna, Montserrat
Soutullo, César
Leza, Juan Carlos
Mico, Juan Antonio
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  Estadisticas en RECOLECTA
(LA Referencia)

BMC Psychiatry 12(200) : (2012)
URI
http://hdl.handle.net/10810/10136
Abstract
[EN] Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP),and to assess its relationship with familiar environment measured using the Family Environment Scale (FES). Methods: We included 82 HC and 14 HC-FHP aged between 9 and 17 years. Total antioxidant status,lipid peroxidation, antioxidant enzyme activities and glutathione levels were determined in blood samples. Results:There was a significant decrease in the total antioxidant level in the HC-FHP group compared with the HC group (OR = 2.94; p = 0.009), but no between-group differences in the Global Assessment of Functioning (GAF) scale scores. For the FES, the HC-FHP group had significantly higher scores in the cohesion (p = 0.007) and intellectual-cultural dimensions (p=0.025). After adjusting for these two FES dimensions, total antioxidant status remained significantly different between groups (OR = 10.86, p = 0.009).
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