Search
Now showing items 121-130 of 160
High resolution imaging to unveil the subcellular layout of the cannabinoid type-1 receptor in rodent models of brain disease
(2020-02-28)
The present Thesis focuses on the description of new subcellular localizations of CB1 receptors in normal brain and the study of the CB1 receptor expression in certain pathophysiological states. Different histological ...
Signaling pathwais in oligodentdrocytes to promote myelin remodeling
(2022-03-16)
Oligodendrocytes make myelin and support axons metabolically with lactate. Experience and neuronal activity can induce dynamic changes in myelination during development and in adult life, suggesting a new form of plasticity ...
Isolation, characterization and selection of new Campylobacter specific bacteriophages to use as biocontrol agents
(2020-02-28)
Con el objetivo de desarrollar una herramienta innovadora, basada en la aplicación de bacteriófagos, para el biocontrol de Campylobacter, se aislaron 304 bacteriófagos a partir de muestras de carne de pollo (280) y excrementos ...
Ocoxin osagarri naturalaren eragin antitumorala pankreako minbiziko eta kolon-ondesteko minbiziaren metastasi hepatikoko eredu esperimentaletan.
(2020-12-22)
Pankreako minbiziak eta kolon-ondesteko minbiziaren metastasi hepatikoak heriotza ugari eragiten dituzte urtero. Hauek tratatzeko erabiltzen den teknika nagusienetariko bat kimioterapia da, zeinak pazienteengan zehar-efektu ...
Activity of carvacrol, cinnamaldehyde, citral and thymol, and their monoolein-based liposomes against oral biofilm-producing Candida isolates
(2021-11-05)
Las candidiasis orales son infecciones fúngicas comunes, causadas principalmente por Candida albicans. Sin embargo, actualmente otras especies de Candida menos sensibles a los fármacos antifúngicos han aumentado su ...
Micro and Macro-Evolutionary Studies in Non-Model Species: a Transcriptomic Perspective in Teleosts
(2021-12-21)
Los recursos genómicos y las herramientas bioinformáticas son muy escasas en especies no modelo. ElRNA-Seq puede ser una herramienta efectiva para generar tales recursos genómicos con el objetivo derevelar la variación ...
Arming NK cells with chimeric antigen receptors (CARs) for treatment of refractory and/or relapsed hematological cancers: preclinical study to determine the best cell source.
(2020-02-10)
Acute Lymphoblastic Leukemia (ALL) and Chronic Lymphocytic Leukemia (CLL) are the most prevalent hematological cancers in children and elder patients respectively. Sometimes, standard treatments are not enough for curing ...
Optimizing pharmacotherapy in the elderly using modelling and simulation methods. Application to Bilastine
(2021-11-29)
This research project was designed to acquire a deeper knowledge on how physiological changes during aging mayaffect the pharmacokinetics (PK) and pharmacodynamics (PD). Elderly adults are a vulnerable population due to ...
Biomolecular Characterization of PCNA interacting proteins.
(2020-07-27)
PCNA (Proliferating Cellular Nuclear Antigen) es la abrazadera que es desliza sobre el ADN necesaria para la replicación del ADN y la respuesta al daño. PCNA interactúa con numerosas proteínas a través de una secuencia ...